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Persistent Dyspnea in Post COVID_19 and Pulmonary Function

Persistent Dyspnea in Post-COVID-19 Patients: Value of Cardiopulmonary Exercise Tests

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05228678
Enrollment
70
Registered
2022-02-08
Start date
2022-04-01
Completion date
2024-04-01
Last updated
2022-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

covid_19 Patients

Keywords

post covid_19,dyspnea, cardiopulmonary exercise

Brief summary

COVID-19 has a high spread rate, millions of people have been infected around the world. Patients complained of different symptoms as fever, dry cough and fatigue which is mild in about 80% of cases, but the severity of the case may progress to develop a respiratory distress or respiratory failure, which may require the need for intensive care unit (ICU)

Detailed description

COVID-19 has a high spread rate, millions of people have been infected around the world. Patients complained of different symptoms as fever, dry cough and fatigue which is mild in about 80% of cases, but the severity of the case may progress to develop a respiratory distress or respiratory failure, which may require the need for intensive care unit (ICU) Many patients with mild or severe COVID-19 do not make a full recovery and have a wide range of chronic symptoms for weeks or months after infection. Post-COVID-19 syndrome is defined by persistent clinical signs and symptoms that appear while or after suffering COVID-19, persist for more than 12 weeks and cannot be explained by an alternative diagnosis. Dyspnea is one of the most prevalent symptoms in post-covid-19 patients in up to 29% of patients with post COVID-19 syndrome. Also, persistent dyspnea in post COVID-19 infection is frequent, it is so far, of unknown mechanism. Cardiopulmonary Exercise Test (CPET) is currently the gold standard technique in the differential diagnosis of dyspnea. Cardiopulmonary exercise testing (CPET) is useful in the assessment of subjects with chronic lung conditions as it may help to: 1) recognize physiological factors limiting exercise (with or without the presence of psychogenic limiting factors); 2) identify these factors as potential therapeutic targets; 3) allow quantification of the level of impairment; 4) assess the effects of an intervention; and 5) provide prognostic information.

Interventions

DIAGNOSTIC_TESTcardiopulmonary exercise tests

Spirometry * forced expiratory volume in 1 second (FEV1) % predicted, * forced vital capacity (FVC)% predicted, * forced expiratory volume in 1 second /forced vital capacity FEV1 /FVC

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Confirmed or clinically and radiologically highly suspected Covid19-infection * Symptom duration at least 12 weeks following first occurrence of symptoms * Patients with dyspnea score 2, 3 and 4 on mMRC * No other disease that better could explain the symptoms (dyspnea) than Covid-19

Exclusion criteria

* Age \<18 * pregnant women * terminally ill patients * active covid-19 infection * previous known severe pulmonary or heart disease * inability to perform pulmonary function or cardiopulmonary exercise tests.

Design outcomes

Primary

MeasureTime frameDescription
Assessment of 1. Aerobic capacity 2. Total Lung Capacity (TLC)two yearsAerobic capacity measured as peak oxygen uptake Total lung capacity measured by spirometry

Secondary

MeasureTime frameDescription
Assessment of Walking capacitytwo yearsmeasured by 6 Minute Walk Test

Contacts

Primary ContactAlaa S Ali, assistant lecturer
a_s_a.1990@yahoo.com01064336300
Backup ContactMaiada K hashem, lecturer
maiada.hashem@gmail.com01006559662

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026