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Machine Learning Model for Perioperative Transfusion Prediction

Development and Interpretation of a Machine Learning Model for Perioperative Transfusion Prediction

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05228548
Enrollment
6121
Registered
2022-02-08
Start date
2022-01-13
Completion date
2022-02-01
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Transfusion, Surgery

Keywords

Decision tree, eXtreme garadient boosting, k-nearest neighbors, Logistic regression, Machine learning, Prediction model, Random forest, Red blood cell transfusion, Surgery

Brief summary

This study aimed to develop and interpret a machine learning model to predict red blood cell (RBC) transfusion.

Detailed description

A dataset from a multicenter study involving 6121 patients underwent elective major surgery was analysed. Data concerning patients who received inappropriate RBC transfusion were excluded. Twenty one perioperative features were used to predict RBC transfusion. The data set was randomly split into train and validation sets (70-30). Decision tree, random forest, k-nearest neighbors, logistic regression, and eXtreme garadient boosting (XGBoost) methods were used for prediction. The area under the curves (AUC) of the receiver operating characteristics curves for the machine learning models used for RBC transfusion prediction were compared.

Interventions

Perioperative blood transfusion

Sponsors

Hacettepe University
CollaboratorOTHER
Dokuz Eylul University
CollaboratorOTHER
Saglik Bilimleri Universitesi
CollaboratorOTHER
Bulent Ecevit University
CollaboratorOTHER
Erzincan University
CollaboratorOTHER
Kahramanmaras Sutcu Imam University
CollaboratorOTHER
Ufuk University
CollaboratorOTHER
Istanbul Medeniyet University
CollaboratorOTHER
Marmara University
CollaboratorOTHER
Eskisehir Osmangazi University
CollaboratorOTHER
Inonu University
CollaboratorOTHER
Mersin University
CollaboratorOTHER
Istanbul University
CollaboratorOTHER
Selcuk University
CollaboratorOTHER
Balikesir University
CollaboratorOTHER
Trakya University
CollaboratorOTHER
Necmettin Erbakan University
CollaboratorOTHER
Ankara University
CollaboratorOTHER
Suleyman Demirel University
CollaboratorOTHER
Tobb University of Economics and Technology
CollaboratorOTHER
Akdeniz University
CollaboratorOTHER
Uludag University
CollaboratorOTHER
Ordu University
CollaboratorOTHER
Gazi University
CollaboratorOTHER
TC Erciyes University
CollaboratorOTHER
Hitit University
CollaboratorOTHER
Firat University
CollaboratorOTHER
Karadeniz Technical University
CollaboratorOTHER
Ondokuz Mayıs University
CollaboratorOTHER
Yuzuncu Yil University
CollaboratorOTHER
Namik Kemal University
CollaboratorOTHER
Baskent University
CollaboratorOTHER
Celal Bayar University
CollaboratorOTHER
Osmaniye Government Hospital
CollaboratorOTHER_GOV
Diskapi Teaching and Research Hospital
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

* Adult * Underwent major elective surgery

Exclusion criteria

* Pediatric patients * Emergency cases

Design outcomes

Primary

MeasureTime frameDescription
Number of patients received Red blood cell transfusionPerioperative periodNumber of patients received Red blood cell transfusion
The area under the curvePerioperative periodThe the area under the curve of the receiver operating characteristics curves

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026