Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05227586

Enrollment

195

Registered

2022-02-07

Start date

2021-11-01

Completion date

2022-01-20

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Persistent Atrial Fibrillation, Right Atrial Enlargement

Keywords

Atrial fibrillation, Right atrium

Brief summary

This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.

Detailed description

This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive RA ablation. We enrolled 65 patients with persistent atrial fibrillation and right atrial enlargement received adjunctive right atrial ablation. These patients were 1:2 match with 130 patients received left atrial ablation only. Atrial fibrillation recurrence rate and other paremeters were analyzed to evaluate the efficacy of adjunctive right atrial ablation in this subset of patients.

Interventions

PROCEDURECircumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation

Patients receive circumferential pulmonary vein isolation and linear ablation (ablation of a roof line and a mitral isthmus line) combined with bi-atrial mapping and left atrial driver ablation.

PROCEDURECircumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation

Patients receive circumferential pulmonary vein isolation and linear ablation (ablation of a roof line and a mitral isthmus line) combined with bi-atrial mapping , left atrial driver ablation and right atrial driver ablation.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Inclusion criteria

1. Aged 18 to 80 years old; 2. Persistent AF with right atrial enlargement; 3. Nonresponse or intolerance to ≥1 antiarrhythmic drug.

Exclusion criteria

1. History of catheter ablation; 2. valvular heart disease; 3. hypertrophic cardiomyopathy or dilated cardiomyopathy; 4. Without follow-up data

Design outcomes

Primary

Measure	Time frame	Description
atrial fibrillation (AF) recurrence rate	at 12 months post procedure	AF recurrence is defined as presence of documented AF episodes of 30 seconds or longer duration

Secondary

Measure	Time frame	Description
atrial fibrillation (AF)/atrial flutter (AFL)/atrial tachycardia (AT) recurrence rate	at 12 months post procedure	AF/AFL/AT recurrence is defined as presence of documented AF/AFL/AT episodes of 30 seconds or longer duration

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026