Retinal Vascular
Conditions
Brief summary
The study aims at evaluating the effect of dark chocolate consumption on anatomy and functionality of retinal blood vessels by comparing these same parameters after milk chocolate consumption.
Interventions
DIETARY_SUPPLEMENTDark chocolate
Patients were administered 20 grams of dark chocolate
DIETARY_SUPPLEMENTMilk Chocolate
Patients were administered 7.5 grams of milk chocolate
Sponsors
Querques Giuseppe
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
* Age of 18 years or older * Healthy volunteers * No vascular diseases * No ocular diseases * Volunteers capable of understanding informed consent
Exclusion criteria
* Patient unable to follow the instructions * Patient unable to come back for follow-up * opacity of lens, cornea, or vitreous * Allergies that contraindicate pupil dilation * Eye diseases * Myopia greater than -8.0 Diopter (D), * Hyperopia greater than 5.0 D * Astigmatism greater than -3.0 D
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retinal perfusion | Baseline, 2 hours after intervention | Changes in retinal perfusion using Optical Coherence Tomography Angiography |
| Retinal vascular response | Baseline, 2 hours after intervention | Changes in retinal vascular response to flicker stimulation using Dynamic Vessels Analysis and Retinal Vessels Analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual Acuity | Baseline, 2 hours after intervention | Best Corrected Visual Acuity changes |
Countries
Italy
Outcome results
None listed