DNER Ataxia
Conditions
Keywords
DNER antibodies, autoimmune cerebellar ataxia, Hodgkin lymphoma
Brief summary
Using a retrospective cohort of 34 patients with DNER ataxia, we will characterize clinical presentation, tumor associations, and outcomes.
Interventions
GENETICDescription of clinical characteristic and genetic tumors
This is a non-interventional study involving clinical data and biological samples (DNA). Clinical data are collected for the center and samples are already stored in biobank repositories and collected as part of good clinical practice in the diagnostic process of patients with suspected autoimmune encephalitis, meaning that the standard diagnostic and therapeutic approaches will not be altered in the selected study population. Patients have already gave explicit written consent for biological specimens sampling and storage at the Centre de Ressources Biologiques des Hospices Civils de Lyon (CRB-HCL) (including tissue, cells or biological fluids) and genetic analysis for research purposes. Additionally, patients will be informed about the present study.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient \> 18 years old * Patient with neurological disorder * Patient with DNER antibodies in sera or CSF
Exclusion criteria
* \- No available clinical data * Patient without DNER antibodies or neurological disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Modified Rankin scale (mRS) | 6 month after the beginning of study | Residual neurological disability as assessed by the modified Rankin scale (mRS) score at last visit) |
Countries
France
Contacts
Primary ContactBastien JOUBERT, MD
Backup ContactMarine VILLARD, RCA
Outcome results
None listed