Desflurane, Electrophysiological Balance Index, QT Interval, Sevoflurane
Conditions
Brief summary
The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.
Interventions
DIAGNOSTIC_TEST12- derivation Electrocardiography
6 precordial and 4 extremity electrodes will be placed at appropriate anatomical points and a total of 6 12-lead ECGs will be taken at different anesthesia depths before anesthesia induction and throughout the operation.
Sponsors
Ankara City Hospital Bilkent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. ASA I-II-III risk group 2. the operation time is longer than 1 hour in the Urology department.
Exclusion criteria
1. bundle branch block in preoperative ECG, 2. Non-sinus heart rhythm, 3. QT length in preoperative ECG, 4. using drugs that cause known QT prolongation ( beta-blocker drugs using will be included), 5. development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period, 6. patients with electrolyte disorders, 7. patient refusal -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| iCEB T0 | Baseline, preoperative | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) |
| iCEB T1 | During surgery (at the time of the anesthesia induction) | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) |
| iCEB T2 | During surgery (at the time of MAC reached 0,6) | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG. |
| QTc T0 | Baseline, preoperative | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR). |
| QTc T1 | During surgery (at the time of the anesthesia induction) | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR). |
| QTc T2 | During surgery (at the time of MAC reached 0,6) | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 0,6, it will be calculated from the ECG. |
| QTc T3 | During surgery (at the time of MAC reached1) | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1, it will be calculated from the ECG. |
| QTc T4 | During surgery (at the time of MAC reached 1,3) | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1,3 , it will be calculated from the ECG. |
| QTc T5 | During surgery (at the time of MAC reduced 0,3) | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reduces 0,3, it will be calculated from the ECG. |
| iCEB T3 | During surgery (at the time of MAC reached 1) | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG. |
| iCEB T4 | During surgery (at the time of MAC reached 1,3) | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG. |
| iCEB T5 | During surgery (at the time of MAC reduced 0,3) | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG. |
Contacts
Primary Contactbetül güven aytaç
Outcome results
None listed