Fertilization in Vitro, Infertility, Female, Thrombophilia
Conditions
Keywords
female infertility, thrombophilia, enoxaparin, abortion, in vitro fertilization, low molecular weight heparin
Brief summary
Retrospective study designed to evaluate outcomes in patients undergoing assisted reproduction. Some of them had thrombophilia, and part of them was treated with enoxaparin, started on the day of embryo transfer, and the other part not. Women without thrombophilia formed the control group.
Detailed description
A retrospective study was performed to evaluate the results in 104 patients undergoing to assisted reproduction. Women without thrombophilia were included as controls (n=20), while women with thrombophilia were either treated with 40 mg daily of enoxaparin (treated group, n=54), initiated on the day of embryo transfer, and continued to the week 36 of gestation, or did not receive this medication (untreated group, n= 30).
Interventions
DRUGEnoxaparin
Women with thrombophilia were treated with 40 mg daily of enoxaparin (treated group), initiated on the day of embryo transfer, up to week 36 of gestation
Sponsors
Faculdade de Medicina do ABC
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Women with female infertility or unexplained infertility * Normal sperm analysis
Exclusion criteria
* Women who did not agree with in vitro fertilization techniques
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with detectable fetal heartbeat | Day 28 | A transvaginal ultrasound was performed for detection of fetal heartbeat |
| Number of participants with detectable ongoing pregnancy | Week 12 | Ongoing pregnancy was detected by ultrasound at twelve weeks |
| Number of participants who delivered a live baby | Week 36 | Live birth was considered delivery that resulted in at least one live born neonate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with biochemical gestation detected | Day 14 | Serum beta-HCG detected 14 days after embryo transfer |
Countries
Brazil
Outcome results
None listed