Peripherel Perfusion Index to Predict Sepsis in Very Low Birth Weight Infants

Study of Peripherel Perfusion Index to Predict Late Onset Sepsis in Very Low Birth Weight Infants

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05224921

Enrollment

216

Registered

2022-02-04

Start date

2022-01-01

Completion date

2022-12-31

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

VLBW - Very Low Birth Weight Infant

Keywords

Late onset sepsis, Peripheral perfusion index

Brief summary

To explore the predictive value of peripheral perfusion index in late onset sepsis of very low birth weight infants , obtain the threshold by observing the perfusion index of very low birth-weight infants within one month after birth, this value can be used as a threshold to predict late onset sepsis in very low birth weight infants.

Detailed description

From the day the very low birth weight infant was admitted to hospital, monitoring was recorded once a day, and continuous monitoring was recorded for 1 month. Before collection, the infant was confirmed to be in supine position with neutral temperature, and at the same time, the infant was in a quiet state, without the contact and operation of medical personnel. This study will first use LMS curve to fit the trend of perfusion index in very low birth weight infants within one month after birth.The perfusion index threshold of the outcome index was determined by ROC curve.

Interventions

OTHERNot applicable (cohort study)

This is a prospective observational study and does not include interventions. The exposure is peripheral perfusion index and the outcome is the incidence of late onset sepsis. From the day when the very low birth weight infant is admitted into hospital, PPI monitoring should be recorded once a day, and continuous monitoring would be recorded until 1 month after birth. Before collection, the infant will be confirmed to be in supine position with neutral temperature, and at the same time, the infant will be in a quiet state, without the contact and operation of medical personnel.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

0 Hours to 3 Days

Healthy volunteers

Inclusion criteria

* Infants weighting \<1500g * Infants admitted to Children's Hospital of Fudan University

Design outcomes

Primary

Measure	Time frame	Description
Incidence of late onset sepsis	From admission into the ward to one month after birth	Neonatal infection occurring 7 days after birth, confirmed by a doctor through laboratory positive indicators or clinical diagnosis

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026