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Clinical Validation of Machine Learning Triage of Chest Radiographs

Clinical Validation of Machine Learning Triage of Chest Radiographs

Status
Withdrawn
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05224479
Enrollment
0
Registered
2022-02-04
Start date
2022-08-31
Completion date
2022-11-30
Last updated
2022-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chest--Diseases

Brief summary

Artificial intelligence and machine learning have the potential to transform the practice of radiology, but real-world application of machine learning algorithms in clinical settings has been limited. An area in which machine learning could be applied to radiology is through the prioritization of unread studies in a radiologist's worklist. This project proposes a framework for integration and clinical validation of a machine learning algorithm that can accurately distinguish between normal and abnormal chest radiographs. Machine learning triage will be compared with traditional methods of study triage in a prospective controlled clinical trial. The investigators hypothesize that machine learning classification and prioritization of studies will result in quicker interpretation of abnormal studies. This has the potential to reduce time to initiation of appropriate clinical management in patients with critical findings. This project aims to provide a thoughtful and reproducible framework for bringing machine learning into clinical practice, potentially benefiting other areas of radiology and medicine more broadly.

Interventions

OTHERTraditional workflow triage

Workflow triage is based on order location, STAT designation, and first-in-first-out status.

OTHERMachine learning workflow triage

Workflow triage is based on the machine learning model's confidence of abnormality.

OTHERRandom workflow triage

Workflow triage is based on random order.

Sponsors

Society of Thoracic Radiology
CollaboratorUNKNOWN
Stanford University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)

Masking description

Radiologists will be blinded when using machine learning and random triage methods.

Intervention model description

Radiologists will triage chest radiographs using traditional, machine learning, and random methods.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Radiologist at Stanford Hospital and Clinics

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
Turnaround timeup to 1 hourTime from completion of radiograph to time that radiologist issues an assessment via preliminary or final report

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026