Clinical Manifestation of COVID-19, Duration of Hospitalization
Conditions
Brief summary
In order to compare the effectiveness between Remdesivir and Favipiravir, an observational analytic study using a retrospective cohort design. Eighty-eight medical records of COVID-19 patients from January to August 2021
Detailed description
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2). Antiviral therapies are considered to be one of the COVID-19 treatments. Remdesivir and favipiravir are the antivirals recommended by Indonesia's 3rd COVID-19 Management Guidelines. They have a similar mechanism to inhibit virus replication, specifically by inhibiting RNA-dependent RNA polymerase (RdRp) of the virus. Several studies reported that patients who received these antivirals had a lower duration of hospitalization. However, the effectiveness comparison of remdesivir and favipiravir remains unknown. An observational analytic study using a retrospective cohort design. Eighty-eight medical records of COVID-19 patients from January to August 2021 are collected by consecutive sampling technique, and this research was carried out at Gotong Royong Hospital Surabaya.
Interventions
DRUGRemdesivir
The patients, based on their clinical condition, got remdesivir OR favipiravir at least five days of treatment. The WHO ordinal scale was used to assess patients' clinical progress in the first and second weeks.
Sponsors
Bernadette Dian Novita, MD.,PhD
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 97 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients (eighteen years old or above) with moderate to severe COVID-19 (categorized based on KEPUTUSAN MENTERI KESEHATAN REPUBLIK INDONESIA NOMOR HK. 01. 07/MENKES/413/2020); * Admitted to Gotong Royong Hospital Surabaya from January 2021 to August 2021; * Received remdesivir OR favipiravir with minimal five days of treatment * Not in pregnancy and lactating condition
Exclusion criteria
* female patient with pregnancy and lactation * patient whom was passed away or forced home during two-weeks observation period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical manifestation | 2 weeks since drug (remdesivir OR favipiravir) administration | Oxygen needs, cough, dyspnea |
Countries
Indonesia
Outcome results
None listed