Left Ventricle Abnormality
Conditions
Brief summary
This study will compare the accuracy of a real-time Cine sequence in assessing cardiac volumetry.
Detailed description
This is a single-centre prospective study involving up to 570 patients with known or suspected cardiac disease referred for routine clinical cardiovascular magnetic resonance (CMR) assessment at Glenfield General Hospital, Leicester. In addition to standard multi-breath-hold steady-state free precession (SSFP) imaging (undertaken as part of the routine scan), each patient will also undergo additional imaging with a non-breath-hold multi-slice real-time cine sequence. The primary outcome is the assessment of cardiac volumetry and function (end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and myocardial mass) as measured by (1) the standard multi-breath-hold SSFP technique and (2) the non-breath-hold multi-slice real-time cine sequence. Secondary outcome measures will be (1) the time required for each scan, and (2) image quality for each scan. An additional secondary outcome will be to compare indexed cardiac volumes with those indexed according to measured body-surface area.
Interventions
DIAGNOSTIC_TESTcardiovascular magnetic resonance
CMR scan at 3 Tesla
Sponsors
University of Leicester
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients aged ≥ 18 years 2. Referred for routine CMR imaging 3. Willing and able to give informed consent 4. Willing and able to comply with the requirements of the study 5. Able to understand written English
Exclusion criteria
1. Severe claustrophobia 2. Absolute contraindications to CMR (those with CMR conditional or safe devices will be eligible for inclusion) 3. Unable to provide informed consent 4. Participants unable to understand written English
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac strain assessment 2 | 1 day | Left ventricular global circumferential strain |
| Cardiac volumetric assessment 4 | 1 day | Right ventricular ejection fraction |
| Cardiac volumetric assessment 5 | 1 day | Right ventricular end-diastolic volume |
| Cardiac strain assessment 1 | 1 day | Left ventricular global longitudinal strain |
| Cardiac volumetric assessment 1 | 1 day | Left ventricular ejection fraction |
| Cardiac volumetric assessment 2 | 1 day | Left ventricular end-diastolic volume |
| Cardiac volumetric assessment 3 | 1 day | Left ventricular myocardial mass |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Image quality assessment | 1 day | Image quality of each scan component, assessed visually on a 4-point score - excellent (3), good (2), moderate (1) and poor (0). |
| Body-surface area | 1 day | planimetered body-surface area |
| Time | 1 day | the time required for each scan under evaluation (real-time Cine and standard Cine) |
Countries
United Kingdom
Contacts
Primary ContactJayanth Arnold, BMBCh
Backup ContactMohamed Elshibly
Outcome results
None listed