Respiratory Insufficiency Requiring Mechanical Ventilation
Conditions
Keywords
Respiratory Failure, weaning difficulty
Brief summary
Acupuncture is a treatment intervention used globally for a wide variety of disorders. Its efficacy has been established over the course of 3000 years, originating in Asia and diversifying worldwide.The scientific basis for acupuncture remains unclear. Nonetheless, acupuncture releases neurochemical substrates, such as endorphins, serotonin, and norepinephrine.Acupuncture is considered to be a safe treatment when applied by a certified acupuncturist.Acupuncture has already been deployed in the treatment of sepsis or muscle weakness.Studies have revealed that acupuncture significantly improved grip strength and respiratory muscle strength in chronic obstructive pulmonary disease participates.Neuromuscular electrical stimulation (NMES) is an alternative to mobilize and exercise because it does not require active patient participation and can be used on bedridden patients.The investigators designed a study to compare the effects of acupuncture, electroacupuncture, and neuromuscular electrical stimulation on mechanical ventilation patients with weaning difficulties
Interventions
BEHAVIORALelectroacupuncture
The acupuncture treatment will be performed by the technique of lifting, thrusting, twirling and rotating the needle until the patient is being De-qi (getting a numbness or other acupuncture feeling).The needle will be kept in place for approximately 30 minutes. The point of acupuncture is determined by a traditional Chinese medicine doctor. Neuromuscular Electrical Stimulation(NMES) group received consecutive daily sessions of electrical stimulation at specific points. On the basis of the above acupuncture treatment,two points that do not cross the joint will be chosen for electrical stimulation in electroacupuncture group.
Sponsors
The Affiliated Hospital of Qingdao University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Prolonged mechanical ventilation duration (\>72 h) * stable oxygen saturation, fraction of inspired oxygen≤55%, and positive end expiratory pressure (PEEP)≤8 cmH2O * dose of dopamine\<10 μg/kg/min and dose of epinephrine\<0.4 μg/kg/min; * mean arterial pressure\>75 mmHg and urine output\>1 mL/kg/h * good healing of the incision after surgery; * normal cognitive function * no history of chronic mental illness or chronic obstructive pulmonary disease
Exclusion criteria
* Inability to perform physical activities * long-term MV prior to admission * neurological comorbidities involving muscles * irreversible disorders with a 6-month mortality rate of\>50% according to Acute Physiology and Chronic Health Evaluation II (APACHEII) * unsound limbs or unstable fractures * administration of glucocorticoids (prednisone or other corticosteroid dose equivalents\>20 mg/day) for at least 20 days prior to admission * cardiopulmonary resuscitation before admission to the ICU * radiotherapy or chemotherapy within the previous 6 months * presence of comorbidities, including acute myocarditis, deep venous thrombosis/embolism, and cerebrovascular accident * Patients with implanted pacemakers or defibrillators * Pregnancy and lactation patients * Patients with active bleeding or bleeding tendency * Skin infection or injury at the acupuncture site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator-free days at 28 days | up to 28days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diaphragmatic thickening fraction(DTF) | baseline,Day 3 of mechanical ventilation,Day 7 of mechanical ventilation,before extubation | DTF shows varied thickness of the diaphragm at end-expiration and end-inspiration. Te maximum and minimum values of each breathing cycle were taken as the end-inspiratory diaphragm thickness (DTei) and the end-expiratory diaphragm thickness (DTee), respectively. DTF was calculated by DTF=(DTei DTee)/DTee 100%. The values for 3 consecutive respiratory cycles were recorded and the average value was taken as the final value |
| Parasternal Intercostal Muscle Ultrasound | baseline,Day 3 of mechanical ventilation,Day 7 of mechanical ventilation,before extubation | A 10-15 MHz linear array transducer was positioned perpendicular to the anterior thorax surface in the longitudinal scan, at the level of the second right intercostal space, approximately 6 to 8 cm lateral to the sternal edge with a window visualizing the second and third ribs. . Using M-mode, the ultrasound beam was perpendicularly directed at the midsection of the muscle, where it is the thinnest at end-expiration. The thickness of the parasternal intercostal muscle was measured on frozen images at end expiration and at peak inspiration. |
Countries
China
Contacts
Primary ContactZehua Dong, Dr.
Outcome results
None listed