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Management and Outcome of Fever in Children in Europe

Personalised Risk Assessment in Febrile Illness to Optimise Real-life Management Across the European Union (PERFORM)

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05221437
Acronym
MOFICHE
Enrollment
38480
Registered
2022-02-03
Start date
2017-01-01
Completion date
2021-12-31
Last updated
2022-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic Prescription

Brief summary

This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe.

Detailed description

This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe. This study will use large departmental datasets to collect information on at least 50,000 febrile episodes . This study will use large-scale, pseudo-anonymized departmental data, and will not involve consented patient recruitment; nor will it use patient samples. Data included in MOFICHE will be based on that collected as part of routine clinical care. Antibiotic prescription, hospitalisation and number/type of investigations, re-attendance at ED within 5 days of the first hospital presentation will be recorded.

Interventions

OTHERantibiotic prescription

Sponsors

Imperial College London
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No

Inclusion criteria

* aged 0- 18 years visiting the emergency care. * fever measured at ED or history of (measured) fever less than 3 consecutive days prior to presentation at emergency department

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Antibiotic prescriptionone yearnumber of antibiotic prescriptions
hospitalizationone yearnumber of children requiring admission to hospital
Number of investigationsone yearnumber of investigations
Number of children re-attending within 5 days of the first hospital presentation.one yearNumber of re-attendance

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026