Keratoconus, Stable
Conditions
Brief summary
This project aims at non-progressive keratoconus patients with unsatisfactory visual acuity corrected by spectacles, and explores the effectiveness and maintenance of visual acuity improved by perceptual learning.
Interventions
DEVICEspectacles
Spectacle is the the most common treatment for refractive errors.
DEVICEperceptual learning
Blurred vision from the eyes can be improved by enhancing the brain's visual processing.
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
9 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Aged 9 years or older; 2. Has been diagnosed as Keratoconus,BAD-D≥2.6; 3. Change of Kmax \< 1.0 D and change of BAD-D \<0.4175 betweem the last two Pentacam result; 4. The best corrected visual acuity of both eyes was between 0.1 and 1.0; 5. Has voluntarily agreed to participate in the study by signing the statement of informed consent.
Exclusion criteria
1. Has history of acute keratoconus; 2. Has other eye diseases or other diseases/conditions causing vision loss; 3. Has eye surgery history in the past 1year; 4. Is currently using local/systemic medications or other interventions that may affect visual function; 5. Receiving other treatments that may affect the results of this study, such as contact lenses during the study; 6. Has any known neurological diseases; 7. Participating in other studies currently that may affect the results of this study; 8. Study other reasons that the physician considers inappropriate for inclusion in the program.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 3-months corrected visual acuity | baseline；3 months. | Mean changes of best corrected visual acuity between 3 months after perceptual learning training and baseline values. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| corrected visual acuity of other time frame | 6,9,15 months | Mean changes of best corrected visual acuity for 6,9,15 months. |
| ucorrected visual acuity (UCVA) | 3,6,9,15 months | Mean changes of ucorrected visual acuity (UCVA) for 3,6,9,15 months. |
| contrast sensitivity function (CSF) | 3,6,9,15 months | Mean changes of contrast sensitivity function (CSF) for 3,6,9,15 months. |
Countries
China
Outcome results
None listed