Parkinson Disease, Stroke, Visual Impairment
Conditions
Keywords
Stroke, Visual field, Oscillations, tACS, Parkinson's Disease
Brief summary
This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients suffering from visual field defects.
Interventions
OTHERCross-frequency dual-site tACS
Dual site transcranial alternating current stimulation over the primary visual cortex (V1) and the mediotemporal cortex (MT/V5) using two different stimulation frequencies (Alpha and Gamma)
Sponsors
Ecole Polytechnique Fédérale de Lausanne
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Masking description
Double (Participant & Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. the patient can consent for themselves; 2. age 18+ years old; 3. at least 7 days since diagnosis stroke. 4. Patients should demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field
Exclusion criteria
1. Diminished capacity to consent; 2. Pregnancy 3. Known or suspected non-compliance, drug or alcohol abuse 4. Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant, 5. Non-compliance to the instructions of the experimenter or an inappropriate behavior hindering the normal progress of the experiment. 6. Previous enrolment into the current study 7.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in visual field functions | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) | Comparison of the systematic measurement of the visual field using Humphrey perimetry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in motion discrimination and integration performances | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) | Comparison of the motion coherence threshold extracted from a two forced-choice direction discrimination task |
| Changes in inter-areal cross-frequency interaction | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) | Comparison of the inter-areal Alpha-Gamma coupling using electroencephalography recordings |
| Changes in visual tracts integrity | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) | Comparison of the diffusion weigted imaging-based tractography of the main visual tracts |
| Changes in functional connectivity within the broad visual network | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) | Functional MRI based connectivity analyses using DCM or graph theory will perfomed |
Countries
Switzerland
Outcome results
None listed