Cancer Patients
Conditions
Keywords
IMRT, Radiotherapy, Immune checkpoint inhibitor, Pneumonitis, Risk factors
Brief summary
The purpose of this non-interventional study is to collect data on the risk factors for acute radiation pneumonitis in patients with prior receipt of immune checkpoint inhibitors.
Detailed description
1. Incidence of acute radiation pneumonitis (aRPs) in in patients with prior receipt of immune checkpoint inhibitors. 2. Risk factors (especially analysis of the dosimetric risk factor) which may affect the product of aRPs events. 3. Establish a model to predict aRPs and guide clinical treatment.
Interventions
RADIATIONCancer patients underwent thoracic intensity-modulated radiotherapy
Cancer patients underwent thoracic intensity-modulated radiotherapy, previously received ICIs
Sponsors
Hubei Cancer Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Pathologically or cytologically confirmed malignant tumor 2. Cancer patients with previously received ICIs underwent thoracic intensity-modulated radiotherapy
Exclusion criteria
1. Cancer patients did not receive immunotherapy before thoracic intensity-modulated radiotherapy 2. Non-thoracic radiotherapy patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of acute radiation pneumonitis (aRPs) in patients with prior receipt of immune checkpoint inhibitors. | 6 months after last-patient- radiation | All suspected diagnoses of pneumonitis (regardless of grade) were centrally reviewed by a multidisciplinary committee consisting of at least one radiologist, pulmonologist, and oncologist. CT (or PET-CT) imaging was reviewed for each patient, which was then compared to the radiation treatment plan; other causes such as infection or tumor progression had to be ruled out using the appropriate workup. |
Countries
China
Contacts
Primary ContactGuang Han, MD.;Ph.D
Outcome results
None listed