Conversion Disorder, Functional Neurological Symptom Disorder, Ketogenic Dieting, Non Epileptic Seizures
Conditions
Brief summary
The objective of this study is to determine the effects of the ketogenic diet on the frequency of non-epileptic seizures in patients with functional neurological symptoms disorder compared to a healthy diet.
Detailed description
This study consists of a open label randomized controlled clinical trial comprised of 20 patients with diagnosis of functional neurological symptom disorder with non epileptic seizures distributed in 2 arms of 10 patients each. Patients will be randomly assigned to one of the groups. Both groups will be receiving treatment as usual (SSRI and/or psychotherapy). One group will be assigned a ketogenic diet while the other will be assigned a healthy diet, both supervised by a team of nutritionists. Patients will be evaluated every 2 weeks until reaching 6 weeks.
Interventions
DIETARY_SUPPLEMENTketogenic dieting
Atkins modified diet: 1.2-1.5 g/kg/day of protein with a ratio 1:1 (fat: carbohydrate + protein)
DIETARY_SUPPLEMENThealthy dieting
Normocaloric diet established by a nutritionist. 1.2-1.5 g/kg/day of protein with a maximum contribution of 50 % carbohydrates of the total calorie intake eliminating industrialized food.
Sponsors
El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who have a record at the institute and who have a diagnosis of a dissociative neurological symptom disorder with non-epileptic seizures with a certainty of at least clinically established who have a monthly seizure frequency greater than 3. * Patients with the characteristics described above with comorbid epilepsy but who have not presented epileptic seizures in the last month. * Patients with the aforementioned characteristics and who give their informed consent in writing to participate in the study. * Patients who, once the diet has been explained to them, consider it feasible to implement it at least for the follow-up time.
Exclusion criteria
* Patients with metabolic or hemodynamic instability, liver failure, inability to tolerate the oral route, acute pancreatitis or pregnancy due to the possible teratogenic effect that has not yet been elucidated. * Patients with metabolic disorders such as primary carnitine deficiency, palmitoyltransferase carnitine I or II deficiency, carnitine translocase deficiency, beta oxidation defects, pyruvate carboxylase deficiency, porphyria and other fatty acid transport and oxidation disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| non epileptic seizure frequency | 2 weeks | number of non epileptic seizures the patient reports on a written crisis record with the aid of a caregiver if necessary |
Countries
Mexico
Outcome results
None listed