Bariatric Surgery Candidate, Obesity, Morbid
Conditions
Keywords
Obesity, Bariatric Surgery, Cognitive Screening
Brief summary
Study is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.
Detailed description
Patients with morbid obesity have shown to be at increased risk for memory loss and cognitive decline. Obesity and high-fat diets have been associated with deficits in learning, memory, and executive functioning. Bariatric surgery results in significant weight loss for patients and helps resolve obesity-related comorbidities such as diabetes and high blood pressure. Interestingly, bariatric surgery has shown promise in improving some aspects of cognitive function and improved memory. (3-1) Obesity affects brain structure, more specifically the grey and white matter, likely in part by reducing oxygen flow to the various regions in the brain. Studies have shown a correlation between BMI and cerebral blood flow velocity (CBFV), where higher BMI is associated with lower CBFV. Although it is not clear how exactly obesity plays a role in the brain's structural and functional changes, observations revealed compromised grey and white matter integrity, its fiber connectivity or cortical atrophy and metabolic alterations. (2) Few studies exist on the impact of bariatric surgery on cognition. Some studies have shown that patients with obesity who underwent bariatric surgery had memory and cognitive improvement compared to those who had not undergone surgery. (4) Thus, the investigators hope to add to our understanding of how bariatric surgery can improve cognitive decline and to potentially offer surgery to more patients with baseline cognitive impairment and to improve cognitive function overall for patients with obesity. More longitudinal studies need to be done to connect bariatric surgery effects with cognitive decline, specifically memory.
Interventions
BEHAVIORALSurgery
Study subjects scheduled for or have already completed weight loss surgery and have already completed psychological screening as part of their pre-surgery work up
Sponsors
University of California, Davis
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Cognitive impairment/decline, memory impairment/loss, or Alzheimer's disease or dementia and bariatric surgery • Cognitive impairment/decline, memory impairment/loss, or Alzheimer's disease or dementia and obesity, and no bariatric surgery history
Exclusion criteria
* Patients without a history of memory impairment/loss, bariatric surgery, or obesity * Patients outside of University of California Davis Health System * Patients unable to provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| California Verbal Learning Test-3rd Edition (CVLT-3) | Pre-operatively | Measures episodic verbal learning including Verbal Learning, immediate memory, and delayed memory |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brief Visuospatial Memory Test | Pre-operatively and 12 months after index screening/date of surgery | Measures visuospatial learning and memory, including visual learning, immediate memory, and delayed memory. |
| Trial Making Test, A & B | 12 months after index screening/date of surgery | Measures visual spatial attention, motor speed and cognitive flexibility |
| WAIS-IV Digit Span Forward & Backward | Pre-Operatively | Measures auditory Attention (Forward), and Auditory attention and working memory (Backward) |
| Verbal Fluency, Phonemic & Semantic | Pre-operatively | Measures verbal fluency by a word generation task based on letter & category (executive functioning) |
| Stroop Color and Word Test; Word, Color & Word-Color | Pre-Operatively | Measures reading speed (word), naming speed (processing) and selective attention and inhibition (attention/executive functioning) |
Countries
United States
Outcome results
None listed