Bleeding Disorder
Conditions
Keywords
von Willebrand disease, hemophilia A and B, other coagulant factor deficiencies
Brief summary
The investigators try to improve the screening of bleeding disorders in children by identifying symptoms, laboratory abnormalities and clinical scores discriminating patients congenital bleeding disorders in order to create a simple screening algorithm applicable in pediatrics, aiming for use in pre-anesthetic consultation and in consultation by pediatricians and general practitioners.
Detailed description
Objective : To determine simple clinical and biological factors that can improve the screening of hemostatic diseases at risk of hemorrhage in children. Method: * Retrospective inclusion of all patients \<18 years referred to the CRTH in pediatric consultation for the reason of exploration of a hemorrhagic syndrome or exploration of an anomaly in the hemostasis assessment. * Data collected (by collection in the medical file): Patient data: Age, sex, personal and family history of hemorrhagic disease Clinical data: hemorrhagic symptomatology (epistaxis, gingivorrhagia, etc.) Biological data: PT, TCK, factor assay, platelet function Medical data: complete diagnosis if diagnosis of hemorrhagic disease * Scores: HEMOSTOP, PBQ, ISTH, TOSETTO score * Analyzes: calculation of the Odd Ratio, AUC, Se, Sp, VPP, VPN for different clinical / biological factors and each score.
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* referred by their general practitioner or another caring physician for evaluation of bleeding symptoms * abnormal laboratory test results or family study * the patient being the first-degree relative of a patient with a known bleeding disorder.
Exclusion criteria
\- older than 18 years old.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Observe the correlation between the data of the interrogation | 1 day | Observe the correlation between the data of the interrogation, the clinical examination and the clinical history and the demonstration of a confirm congenital bleeding disorder. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Test scores | day 1 | Test scores (HEMOSTOP, TOSETO ...) to propose a simple algorithm for carrying out screening assessments for congenital bleeding disorders in children. |
| Compare several scores | day 1 | Compare several scores (HEMOSTOP, TOSETO ...) to propose a simple algorithm for carrying out screening assessments for congenital bleeding disorders in children. |
Countries
France
Outcome results
None listed