COVID-19
Conditions
Keywords
COVID-19, Viral load, Antiseptic, Povidone-iodine, Hypochlorous acid
Brief summary
In a study conducted on 75 COVID-19 patients, the effect of SARS-CoV-2 on viral load was investigated as a result of the use of hypochlorous acid and povidone-iodine as an oral antiseptic.
Detailed description
Before and 30 minutes after rinsing with mouth antiseptics, the participants were asked to rinse the mouth and throat for 30 seconds with 0.9% isotonic saline. The sample was sputtered into a sterile plastic container. The participants were grouped according to the type of oral antiseptics used. The effectiveness of SARS-CoV-2 viral load was investigated by rinsing the mouth and throat for 30 seconds with 20 ml of hypochlorous acid, povidone-iodine, and isotonic saline. Viral load was analyzed by RT-PCR analysis. The results were evaluated by statistical analysis.
Interventions
DRUGHypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)
SARS-CoV-2 sample was obtained from COVID-19 patients by rinsing the mouth and throat with 5 ml of isotonic saline before and 30 minutes after rinsing. In the hypochlorous acid group, 20 ml of HClO was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the povidone-iodine group, 20 ml of PVP-I was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the saline group, 20 ml of saline was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants.
Sponsors
Ataturk University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Positive SARS-CoV-2 RT-PCR result, * Adult hospitalized patient, * The participants have the physical and psychological ability to follow the instructions in the study.
Exclusion criteria
* Patients intubated and supported by a mechanical respirator, * Severe acute or chronic medical or psychiatric condition, * History of significant adverse effects following use of oral hygiene products such as toothpaste and mouth rinses, * Active uncontrolled thyroid disease, * Developmental/cognitive disability, * Pregnancy, * Undergoing radioactive iodine therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RT-PCR analysis | two weeks | For the quantitative analysis of the amount of SARS-CoV-2 RNA in the obtained samples, the Real-time Reverse Transcyptase Polymerase Chain Reaction method was used. |
Countries
Turkey (Türkiye)
Outcome results
None listed