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Effects on Glucose Homeostasis of Changes in Plasma Lipoproteins Induced by Nutritional and Pharmacologic Strategies

Effects on GLUcose Homeostasis of Changes in Plasma Lipoproteins Induced by Nutritional and Pharmacologic STrategies Against Diabetes-Related Metabolic Diseases

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05213988
Enrollment
50
Registered
2022-01-28
Start date
2018-07-30
Completion date
2025-01-01
Last updated
2022-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucose Metabolism Disorders

Brief summary

The investigators aim to examine the impact of changes in plasma lipoproteins induced by nutritional and pharmacological interventions on glucose homeostasis

Interventions

DIETARY_SUPPLEMENTIntermittent Fasting

Intermittent fasting meal pattern

DRUGFibrates

Bezafibrate 400 mg/day

DIETARY_SUPPLEMENTLow-Carbohydrate/High-Protein diet

Low-calorie, low-carbohydrate, high-protein diet

Sponsors

Azienda Ospedaliero, Universitaria Pisana
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* age 18-65 years * both males and females

Exclusion criteria

* acute or chronic conditions influencing glucose and lipid metabolism * pregnancy

Design outcomes

Primary

MeasureTime frameDescription
Glucose tolerance180 minutesGlucose tolerance will be measured as the area under the curve of plasma glucose levels in response to a 180-minute 75g oral glucose tolerance test (OGTT)

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026