Abscess, Infections, Liver Abscess, Liver Abscess, Pyogenic
Conditions
Keywords
Pyogenic Liver abscess, Liver histological change
Brief summary
Pyogenic liver abscess is one of the most common visceral abscesses, its incidence is increasing worldwide. According to the previous literature, the mortality rate of pyogenic liver abscess is as high as 31% and become a serious social health problem. However, the data of prospective observational real-world studies are scarce and no relevant research of the liver histological change has been reported, so the long-term prognosis and the risk factors for pyogenic liver abscess are still unknown. Patients will be followed up prospectively for a period of 2 years and observed clinical prognosis (all-cause mortality, the recurrence rate, and the rehospitalization rate). The investigators will investigate the predictive value of clinical risk factors for clinical prognosis and establish clinical prediction models to predict the long-term prognosis of pyogenic liver abscesses.
Interventions
None listed
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 18 years of age; * Irrespective of gender; * Symptomatic patients of liver abscess confirmed with radiology imaging, either by ultrasonography or computed tomography scan.
Exclusion criteria
* Patients \<18 years old; * Pregnancy at presentation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion and causes of deaths within 2 years of discharge from hospital | 2 years | Define the proportion and causes of deaths within 2 years of discharge from hospital for patients admitted to the Department for pyogenic liver abscesses. |
| Proportion and causes of re-hospitalization within 2 years of discharge from hospital | 2 years | Define the proportion and causes of re-hospitalization within 2 years of discharge from hospital for patients admitted to the Department for pyogenic liver abscesses. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The recurrence rate of pyogenic liver abscess | 2 years | Development new liver abscess after clinical cure during the 2 years follow up period |
| The number of participants with Histological Change in the Liver | 2 years | Assessment of histological change in the liver by using ultrasonography or transient elastography during the 2 years follow up period |
Countries
China
Contacts
Primary ContactXuyen Xu, MD
Backup ContactMuye Xia, MD
Outcome results
None listed