Metabolic Responses After 12-week Hypocaloric Diet Supplemented With a Cereal-based Plant Protein Biscuit

Glucose and Gastrointestinal Hormone Responses of Subjects With Overweight/Obesity After 12-week Hypocaloric Dietary Intervention Supplemented With a Cereal-based Biscuit Enriched With Plant Proteins

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05213559

Enrollment

Registered

2022-01-28

Start date

2022-02-01

Completion date

2023-08-30

Last updated

2023-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetite

Keywords

cereal-based biscuit enriched with plant proteins, appetite regulation, glycemic control, hormone responses

Brief summary

Biscuits enjoy high popularity in the human diet and can be excellent snack alternatives and potential carriers of ingredients with appetite regulating properties. In the present study, the effects of a wheat biscuit enriched with plant proteins originated from legumes and seeds on gastrointestinal hormone responses of women with overweight/obesity after a hypocaloric dietary intervention will be examined.

Detailed description

Women with overweight/obesity will follow a 12-week dietary intervention supplemented with a cereal-based biscuit enriched with plant proteins or a common isocaloric wheat biscuit as a daily snack. At the beginning and at the end of the dietary intervention postprandial metabolic responses, body weight reduction and subjective appetite ratings will be examined.

Interventions

OTHERwheat biscuit enriched with plant proteins

Postprandial glucose and appetite-regulating hormone responses of subjects with overweight/obesity after a 12-week dietary intervention with a biscuit enriched with plant proteins

OTHERcommon wheat biscuit

Postprandial glucose and appetite-regulating hormone responses of subjects with overweight/obesity after a 12-week dietary intervention with a common wheat biscuit

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* non-diabetic women with overweight/obesity * constant body weight for the last three months before enrollment * standard dietary and physical activity habits

Exclusion criteria

* pregnancy * lactation * chronic medical illness * use of nutritional supplements * alcohol consumption \>2 drinks per day

Design outcomes

Primary

Measure	Time frame	Description
change in postprandial glucose response	Time points: 0,30,60,91,120,180 min postprandially at week 0 and week 12.	change in glucose iAUC and glucose concentration at certain time points at the end of the dietary intervention compared to the beginning.

Secondary

Measure	Time frame	Description
change in postprandial appetite regulating hormone responses	Time points: 0,30,60,91,120,180 min postprandially at week 0 and week 12.	changes in iAUCs and concentrations at certain time points at the end of the dietary intervention compared to the beginning.

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026