Chronic Heart Failure
Conditions
Brief summary
To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .
Detailed description
Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .
Interventions
OTHERAerobic exercise training
bicycle ergometer exercise training
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients with following criteria were included : * All patients ages were between 50 - 60 years old * Fractional shortening \< 25% and ejection fraction \< 40% * Sinus rhythm. * Heart Failure due to ischemic heart disease. * New York Heart Association (NYHA) class II-III. * Regular medical treatment.
Exclusion criteria
* Patients with following criteria were excluded : * Chronic heart failure due to other causes * History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension). * Recent acute coronary syndrome or revascularization (3 months). * Exercise limited by angina or peripheral arterial occlusive disease; * Cerebrovascular or musculoskeletal disease preventing exercise testing or training. * Poorly controlled or exercise-induced cardiac arrhythmias * Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ejection fraction | change from baseline to after 12 weeks | represents left ventricular function measured by pulsed echocardiography |
| pro-brain natriuretic peptide (proBNP) | change from baseline to after 12 weeks | biomarker for heart failure measured by analysis of venous samples drawn |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Minnesota Living With Heart Failure Questionnaire (MLWHF): | change from baseline to after 12 weeks | Questionnaire for measuring quality of life of heart failure patients |
Countries
Egypt
Outcome results
None listed