Acute Diarrhea, Acute Gastroenteritis
Conditions
Brief summary
Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. This study aims to evaluate serum levels of interleukins 6 and 8 in children with acute gastroenteritis.
Interventions
DIAGNOSTIC_TESTEvaluation of serum levels of IL-6 and IL-8
Evaluation of serum levels of IL-6 and IL-8 by Luminex Assay (multiplexed ELISA kits)
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Months to 5 Years
Healthy volunteers
No
Inclusion criteria
Group 1: Cases (Children with acute diarrhea) Inclusion Criteria: * Children aged 6 months to 5 years. * Acute diarrhea: defined according to WHO criteria as the passage of loose or watery stools at least three times in a 24 h period, lasts less than 14 days, with or without fever or vomiting, but considering the importance of change in stool consistency rather than frequency, and the usefulness of parental insight in deciding whether children have diarrhea or not.
Exclusion criteria
* Malnutrition or obesity * History of antibiotic therapy in the last 72 hours. * Acute diarrhea in association with systemic infections * Malignancy * Chronic diarrhea * Autoimmune and autoinflammatory diseases. * Chronic renal/liver failure * Diabetes mellitus Group 2: Controls (Healthy control children) Inclusion Criteria: • Healthy children aged 6 months to 5 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum level of Interleukin 6 | Within the first 3 days of acute diarrhea | Difference in serum level of interleukin 6 between cases and control groups |
| Serum level of Interleukin 8 | Within the first 3 days of acute diarrhea | Difference in serum level of interleukin 8 between cases and control groups |
Countries
Egypt
Contacts
Primary ContactJohn s shaker, MBBCH
Backup ContactAshraf M Radwan, MD, PhD
Outcome results
None listed