Ovulation Disorder, Subfertility, Female
Conditions
Keywords
ovulation, progesterone, ovulatory dysfunction, subfertility
Brief summary
Ovulatory dysfunction is identified in 15% of all infertile couples and it accounts for 40% of female infertility. Ovulatory dysfunction may be more subtle in women with regular menses. Detecting the day of ovulation is necessary for optimizing natural conception, diagnosis of cycle disturbances and also timing for embryo transfer in natural cycle frozen-thawed embryo transfers. In order to diagnose ovulatory dysfunction, ovulation physiology and change of reproductive hormones during the menstrual cycle should be understood. In the present study we aimed to evaluate serial serum hormonal cut-off levels referenced to ovulation in subfertile women with regular menses.
Interventions
DIAGNOSTIC_TESTSerum progesterone levels
In order to show change of serum progesterone levels, serial venous blood sampling will be done and also transvaginal ultrasonography will be performed to show ovulation.
Sponsors
Turgut Aydın
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* women that have regular menses (menstrual cycle length 21-35 days) * women who will come visits regularly * women that are trying to conceive more than 1 year if women age is less than 35 years or more than 6 months if women age is \>35 years
Exclusion criteria
* women who do not menstruate regularly * women that use hormonal contraception * women who take drugs that will interfere with steroid hormone metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of serum progesterone levels referenced to ovulation | Progesterone levels will be measured serially when dominant follicule reaches 17 mm in diameter and after that 1-2 days interval until to ovulation; 1 week after ultrasound and hormone-detected ovulation | Serum progesterone levels will be measured when dominant follicule is 17 mm in diameter and then serial measurements of hormones will be done and ovulation will be detected both hormonally and ultrasonographically. The range of serum progesterone will be reported referenced to ovulation. |
| Change of reproductive hormone levels referenced to ovulation | Estradiol and LH levels will be measured serially when dominant follicule reaches 17 mm in diameter and after that 1-2 days interval until to ovulation. | Serum estradiol and luteinising hormone (LH) levels will be measured when dominant folicule is 17 mm in diameter and then serial measurements of hormones will be done and ovulation will be detected both hormonally and ultrasonographically. The ranges for serum hormones will be reported. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactTurgut Aydın
Backup Contactnadiye köroğlu
Outcome results
None listed