Atrial Fibrillation
Conditions
Keywords
atrial fibrillation, atrioventricular node
Brief summary
This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation
Detailed description
Right-sided atrioventricular node ablation has been the initial conventional approach however up to 18.5% of patients require switching to a left sided approach or have a challenging procedure. Previous studies have found that left sided ablation is more efficacious than right-sided ablation requiring less than 5 applications of radiofrequency energy to induce atrioventricular block. This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation
Interventions
PROCEDUREatrioventricular node ablation
atrioventricular node ablation
Sponsors
East Sussex Hospitals NHS Trust
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age greater than or equal to 18 years * Referred for atrioventricular node ablation for any such indication
Exclusion criteria
* Stroke or transient ischaemic attack (TIA) within 6 months * Myocardial infarction within 6 months * Medical conditions limiting expected survival to \<1 year * Moderate to severe aortic stenosis * History of aortic or mitral valve replacement * Pregnancy or breast feeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of total ablation time required to induce complete atrioventricular node block | intraoperative | Time in seconds |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of total procedure time between the two groups | intraoperative | Comparison of total procedure time between the two groups |
| Comparison of radiation exposure between the two groups | intraoperative | Comparison of radiation exposure between the two groups |
| Comparison of rate of the escape rhythm after ablation in beats/min | intraoperative | Comparison of rate of the escape rhythm after ablation in beats/min |
| Comparison of number of RF applications required to induce complete atrioventricular node block | intraoperative | Comparison of number of RF applications required to induce complete atrioventricular node block |
| Comparison of adverse events / complications between each group | intraoperative | Comparison of adverse events / complications between each group |
| Comparison of patient comfort of procedure | intraoperative | Comparison of patient comfort of procedure using visual analogue scale ( 0-100) |
| Comparison of number of patients requiring crossover to each side | intraoperative | Comparison of number of patients requiring crossover to each side |
Countries
United Kingdom
Contacts
Primary ContactRick Veasey
Outcome results
None listed