Periodontal Diseases
Conditions
Keywords
Periodontal disease, Probiotics, Prebiotics
Brief summary
In this randomized controlled trial, it was aimed to evaluate the effect of probiotics (chewable tablets) and kefir consumption in the initial periodontal treatment of periodontitis patients on the change of oral microbiota and treatment. In this clinical trial, 36 systemically healthy volunteers who were diagnosed with periodontitis who were admitted to Gazi University Faculty of Dentistry, Department of Periodontology were included. Besides the inclusion criteria, the nutritional habits of the patients were evaluated by questionnaire. For diagnosis, plaque index, gingival index, bleeding on probing, periodontal probing depth and clinical attachment level were examined. Patients were randomly divided into 3 groups; probiotic, kefir and control group. Following the periodontal diagnosis, clinical index records of the patients and subgingival microbial samples were obtained. The supragingival plaque sample was removed and the subgingival microbial dental plaque sample was gently taken with a sterile Gracey curette. In the same session, periodontal initial treatment was started. According to the groups, they were involved simultaneously with the treatment, kefir group was advised to consume kefir as a liquid once a day in 14 days; probiotics group was advised to consume as a chewable tablet once a day in 14 days; the control group was advised without additional food supplements. Periodontal indexes were repeated in the 1st and 3rd months. Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia (T. forsythia), Porphyromonas gingivalis (P. gingivalis), and Treponema denticola (T. denticola).
Interventions
DIETARY_SUPPLEMENTProbiotics
According to the groups, they were involved simultaneously with the treatment, kefir group was advised to consume kefir as a liquid once a day in 14 days; the probiotics group was advised to consume as a chewable tablet once a day in 14 days; the control group was advised without additional food supplements.
DIETARY_SUPPLEMENTAOÇ Kefir
AOÇ Kefir
OTHERFood without additional food supplements
Food without additional food supplements
Sponsors
Gazi University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
1. Systemically healthy 2. Individuals over 18 3. Periodontitis (4-6 mm pockets) patients with 3 teeth in each half of the jaws except wisdom tooth 4. Non-smoker 5. Not using probiotic tablets/capsules and consuming no more than 3-4 probiotic food.
Exclusion criteria
1. Antibiotic use within 6 months. 2. Breastfeeding or pregnancy. 3. Acute oral lesions or necrotizing ulcerative periodontitis 4. Diabetes, rheumatic fever, lung, kidney disease history and drug use that will affect periodontal tissues 5. Patients who smoke or who did not stop until last year 6. Use of probiotics tablets or capsules 7. Probiotic food consumption not more than 3-4 times a week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Periodontal probing depth | Baseline | the distance from the gingival margin to pocket base. |
| Gingival index | Baseline | It is an index that shows the severity and quantity of gingival inflammation. |
| Microbiological sample | Baseline | Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola. |
| Plaque index | Baseline | It is an index that shows the amount of microbial dental plaque on the teeth. |
| Bleeding on probing | Baseline | Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment level | Baseline | The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus. |
Countries
Turkey (Türkiye)
Outcome results
None listed