The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05209958

Enrollment

Registered

2022-01-27

Start date

2020-06-10

Completion date

2022-01-10

Last updated

2022-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C23.550.470, C23.550.767.700

Keywords

Preemptive Epidural Analgesia, Neutrophil/Lymphocyte Ratio, İnflammation

Brief summary

The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.

Detailed description

The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

Interventions

DIAGNOSTIC_TESTNeutrophil Lynphosite ratio

The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28).

Study design

Observational model

OTHER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III * Patient subjected to thoracotomy operation

Exclusion criteria

Patient having morbid obesity, * Patient having renal failure, * Patient having hepatic failure, * Patient having neuropsychiatric disease, * Patient allergy to the study drugs

Design outcomes

Primary

Measure	Time frame	Description
preoperative neutrophil lymphoycte ratio	24 hours before the operation	To determine the epidural application with preoperative neutrophil lymphoycte ratio
Postoperative opioid requiremen Postoperative opioid requirement	postoperative first 24 hour	Postoperative opioid requirement for pain relief

Secondary

Measure	Time frame	Description
Numerical Pain Rating Scale	postoperative first 24 hour	Numerical Pain Rating Scale in postoperative period

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026