Frailty
Conditions
Keywords
pre-frail, blood flow restriction, functional mobility
Brief summary
This study investigates the effect of blood flow restriction with resistance exercise on functional mobility in pre-frail older adults. It is hypothesized that receiving resistance exercise with blood flow restriction will exhibit better improvement on functional mobility than only receiving resistance exercise in pre-frail older adults.
Detailed description
Participants aged over 65 years old with less than two items positive of Fried frailty phenotype assessment result will be recruited. The participants will be randomly assigned to two training groups, blood flow restriction resistance exercise and traditional resistance exercise. Both groups will receive the training 30 minutes/session, two sessions/week for six weeks. Muscle strength of the lower extremities and functional mobility tests will be used to assess outcomes at pre-training, 3-week after training, post-training, and one-month and two-month follow-up.
Interventions
OTHERResistance exercise on the lower extremities
Resistance exercise mainly on the lower extremities will be executed by carrying weight according to each participant's tolerance while performing certain movements, such as side step-up, sit-to-stand, and tip-toe-standing.
OTHERResistance exercise on the lower extremities with blood flow restriction
Blood flow restriction on the thigh of the dominant leg will be used in combination with resistance exercise.
Sponsors
National Cheng Kung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* Aged over 65 years old * Fried frailty index fulfill 1-2 criteria * Able to walk 6 meters independently * Able to understand and follow ≥ 3 instructions
Exclusion criteria
* Severe hypertension (\>180/110mmHg) * Peripheral neuropathy * History of deep-vein thrombosis (DVT) * Cardiovascular diseases (i.e. Heart failure NYHA Classification III or IV, myocardial infarction, pulmonary hypertension, coronary artery stenosis) * Neuromuscular diseases (i.e. Stroke, Parkinsons' disease) * History of resisted exercise training program within the last 6 months before screening
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Timed-Up and Go (TUG) test | Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention | Timed-Up and Go test |
| Change of 30 seconds sit to stand | Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention | 30 seconds sit to stand test |
| Change of muscle strength of the lower extremities | Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention | Muscle strength of bilateral hip flexors, knee extensors, ankle dorsiflexors and plantarflexors |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of one-repetition maximum | Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention | One-repetiton maximum of side step-ups |
| Change of muscle mass | Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention | Muscle mass of the upper and lower extremities and trunk |
| Change of hand grip strength | Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention | Bilateral grip strength |
Countries
Taiwan
Outcome results
None listed