Cardiovascular Diseases, Metabolic Syndrome
Conditions
Keywords
Postprandial metabolic events
Brief summary
The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals on parameters associated with cardiometabolic diseases. Therefore, older subjects with increased risk of cardiometabolic diseases consume 4 mixed meals with 25 or 50 g of either canola or coconut oil. In a postprandial period of 6 hours, outcomes associated with cardiometabolic risk (e.g., triglycerides) are analyzed.
Detailed description
In a crossover design, 30 older men and women with increased risk of cardiometabolic diseases consume 4 mixed meals, enriched with either 25 or 50 g canola or coconut oil. During a postprandial period of 6 hours, parameters of lipid metabolism (e.g., plasma triglycerides), glucose metabolism (e.g., plasma glucose, serum insulin), as well as markers of inflammation (e.g., IL-6), vascular system (e.g., pulse wave velocity) and antioxidant system (e.g., trolox equivalent antioxidative capacity) are analyzed. Furthermore, fatty acid profile, neuropsychologic parameters (e.g., attention), subjective feeling of hunger and satiety, and satiety-associated hormones (e.g., ghrelin) are assessed. Each intervention arm will be separated by a washout period of about 14 days.
Interventions
DIETARY_SUPPLEMENTMixed meals
Mixed meals enriched with either 25 or 50 g of canola or coconut oil
Sponsors
Union for the Promotion of Oil and Protein Plants (UFOP, Germany)
University of Bonn
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* BMI: 27 - 34,9 kg/m2 * Waist circumference: women ≥ 80 cm, men ≥ 94 cm * At least two of the following criteria of metabolic syndrome: Fasting triglycerides in serum: ≥ 150 mg/dl Fasting HDL-Cholesterol in serum: women \< 50 mg/dl, men \< 40 mg/dl Systolic blood pressure: ≥ 130 mmHg, diastolic blood pressure: ≥ 85 mmHg Fasting glucose in plasma: ≥ 100 mg/dL
Exclusion criteria
* Smoking * Diseases that may impact outcome measures (e.g., thyroid diseases, insulin-dependent diabetes mellitus, impaired renal function, tumors, anemia) * Intake of immunosuppressives or supplements (e.g., fish oil) * Participation in another study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Parameters of glucose metabolism in blood II | Postprandial period of 6 hours | Measurement of insulin (nmol/L) |
| Parameters of lipid metabolism in blood IV | Postprandial period of 6 hours | Measurement of HDL cholesterol (mg/dl) |
| Parameters of lipid metabolism in blood I | Postprandial period of 6 hours | Measurement of triglycerides (mg/dl) |
| Parameters of lipid metabolism in blood II | Postprandial period of 6 hours | Measurement of total cholesterol (mg/dl) |
| Parameters of lipid metabolism in blood III | Postprandial period of 6 hours | Measurement of LDL cholesterol (mg/dl) |
| Parameters of lipid metabolism in blood VI | Postprandial period of 6 hours | Measurement of free fatty acids (mmol/L) |
| Parameters of glucose metabolism in blood I | Postprandial period of 6 hours | Measurement of glucose (mg/dl) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of hunger and satiety | Postprandial period of 6 hours | Assessment via visual analogue scales (e.g., 0 = not hungry at all, 10 = very hungry) |
| Assessment of gut hormones | Postprandial period of 6 hours | Measurement of gut hormones associated with hunger and satiety in blood (ghrelin in pg/ml; PYY in pg/ml) |
| Assessment of attention and memory | Postprandial period of 6 hours | Assessment via validated neuropsychological questionnaires (paper-pencil) |
| Postprandial endothelial function | Postprandial period of 6 hours | Assessment via the Vicorder device (e.g., measurement of pulse wave velocity in m/s) |
| Postprandial inflammation | Postprandial period of 6 hours | Measurement of parameters of inflammation in blood (e.g., IL-6 in pg/ml) |
| Antioxidant system | Postprandial period of 6 hours | Measurement of parameters of antioxidant system in blood (e.g., TEAC in mmol Trolox equivalents/L) |
| Fatty acid profile | Postprandial period of 6 hours | Analysis of fatty acid profile in serum (e.g., alpha-linolenic acid in µmol/L) |
Countries
Germany
Outcome results
None listed