Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
Conditions
Keywords
Colorectal Adenoma, Occult Bleeding, Quantitative fecal immunochemical test
Brief summary
Early detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. In order to reduce the incidence of colorectal cancer, improve the early diagnosis of colorectal cancer, the investigators conducted this study to explore diagnostic accuracy of fecal immunochemical test in colorectal cancer screening population.
Detailed description
Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide. With progress of developing countries, it is predicted that the incidence of colorectal cancer worldwide will increase to 2.5 million new cases in 2035. The majority of colorectal cancer is thought to arise from precancerous lesions through the adenoma-carcinoma pathway. Detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. In order to reduce the incidence of colorectal cancer, improve the early diagnosis of colorectal cancer, the investigators conducted this study to explore diagnostic accuracy of fecal immunochemical test in colorectal cancer screening population.
Interventions
DIAGNOSTIC_TESTFecal Immunochemical Test
Participants with positive fecal immunochemical test results were further examined by colonoscopy.
Sponsors
The People's Hospital of Zhaoyuan City
Shanghe People's Hospital
Shandong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Adults 50-75 years old
Exclusion criteria
* People with history of intestinal surgery; * People with history of colorectal cancer; * People with history of inflammatory bowel disease, ischemic enteritis, vascular malformation of intestine or other disease resulting in intestinal tract bleeding; * People with symptoms including visible rectal bleeding, hematuria, severe and acute diarrhea; * Pregnancy, lactation or menstrual phase; * Severe congestive heart failure or other sever disease cause cannot tolerate colonoscopy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The efficacy of fecal immunochemical test to detect advanced adenoma | 6 months | The detection rate and positive predictive value of fecal immunochemical test to detect advanced adenoma |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The efficacy of fecal immunochemical test to detect colorectal cancer | 6 month | The detection rate and positive predictive value of fecal immunochemical test to detect colorectal cancer |
| The efficacy of fecal immunochemical test to detect colorectal neoplasms | 6 month | The detection rate and positive predictive value of fecal immunochemical test to detect colorectal neoplasms |
Countries
China
Contacts
Primary ContactRuchen Zhou
Backup ContactYanqing Li
Outcome results
None listed