Cerebral Small Vessel Diseases, MRI
Conditions
Keywords
Cerebral small vessel diseases, Cognitive impairments, Lesion burden, MRI
Brief summary
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
Detailed description
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
Interventions
DIAGNOSTIC_TESTMagnetic resonance imaging
Patients recruited will receive Magnetic resonance imaging.
Sponsors
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarcts and white matter hyperintensity * No disability (modified Rankin's scale \< 2) * No dementia (MMSE \> 24 and absence of dependence in daily activities) * Able and willing to consent
Exclusion criteria
* Contraindications to MRI * Standard MRI of bad quality due to movement artefacts * Pregnant * Unable to tolerate MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression in total cerebral small vessel disease burden | 1 year | Total cSVD burden assessed by MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Progression in congnitive impairments | 1 years | Global Z-score by cognitive domain |
| Recurrent ischemic events | 1 year | Recurrent ischemic stroke, TIA and vascular death |
| Modified Rankin Scale | 90 days and 1 year after qualifying event | Disability assessed by modified Rankin Scale (mRS). The scores, ranging from 0 (no symptoms) to 6 (death), were recorded by phone call or outpatient consultation. A favorable outcome was defined as mRS score 0-2, unfavorable outcome was defined as mRS score \> 2. |
Countries
China
Contacts
Primary ContactKun Cheng, M.S.
Outcome results
None listed