Hyperphagia
Conditions
Keywords
emotional overeating, functional near infraRed spectroscopy, neurofeedback, cognitive control
Brief summary
Emotional overeating is characterized by an excessive food intake in the context of intense emotional situations, such as acute stress one. Emotional overeating, as a behavioral trait, can increase the risk of to develop eating disorders or eating-related diseases, such as metabolic syndrome, obesity, type-2 diabetes. Recently, imaging modalities, such as magnetic resonance imaging (MRI) and electro-encephalography (EEG), have been adapted in order to perform neurofeedback consisting on presenting the brain activity instantaneously to the participant, that give him the possibility to modify this activity by his own mean. Neurofeedback has already shown some efficacy, either with explicit or implicit instruction. Compared with functional MRI (fMRI), functional near infra-red spectroscopy (fNIRS) is easy to handle, less expensive, and does not require a lying position. fNIRS is consequently more adapted for repeated acquisitions. Neurofeedback has already shown some promising results for neurological and psychiatric diseases. For mental states and emotion regulation, neurofeedback targeting the prefrontal cortex (PFC) has also shown promising outcomes. In this project, the investigators want to assess the effect of neurofeedback targeting the dorsolateral PFC (dlPFC) in a population of young adult women presenting emotional overeating. The investigators aim to improve the cognitive control and to reduce the episodes of emotional overeating in order to prevent the occurrence of subsequent pathologies. The intervention effect will be characterized with: (i) fMRI in order to evaluate the effect on cognitive control (with resting state fMRI or rsMRI) and on the reward system; (II) questionaries directly and one month after intervention in order to assess the behavioral effect. Besides an expected effect on emotional overeating, the investigators will evaluate whether an improvement of cognitive control can also promote positive effect on other behavioral traits that could lead to some pathologies such as food addiction. As a prerequisite to this study on emotional overeating (study B), the investigators will firstly validate on healthy subjects (study A) a reward anticipation fMRI task, which will be further used in study A in order to characterized the effect of neurofeedback on the reward system.
Interventions
DEVICENeurofeedback with functional near infra-red spectroscopy
the neurofeedback protocol will last 15 minutes per session, and during each session, the volunteer will have to increase the brain activity of his/her dorsolateral prefrontal cortex using a visual gauge representing the activity level of his/her own dorsolateral prefrontal cortex. No specific instructions will be given to the volunteer so that he/she can develop his/her own internal strategy to increase this activity level.
DEVICESham Neurofeedback
the participants will receive the same instruction but will be shown a random signal
OTHERoral microbiota collection
an examination and oral swab for oral microbiota analysis will be performed by a dentist
OTHERQuestionnaires
questionnaires for pre-intervention behavioral characterization
DEVICEresting-state fMRI
characterize the brain function of volunteers by resting-state fMRI
DEVICEElectro gastrogram
Volunteers will also be equipped with an MRI-compatible electro-gastrogram device to correlate gastric signals with brain activity during rsMRI acquisition.
BEHAVIORALEmotional Stroop task
an emotional Stroop task adapted to food and body image representation
Sponsors
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Rennes University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Eligibility Study A : * Minimum age : 18 Years * Maximum Age : 50 Years * Sex : women or men Inclusion Criteria : * Normal Body Mass Index (18.5-25), * Right-handlers * Affiliated to a social security scheme * Having given a free, informed and written consent
Exclusion criteria
: Related to the study - Insufficient command of French Related to Magnetic Resonance Imagine * Implantable cardiac pacemaker or defibrillator; * Neurosurgical clips; * Cochlear implants; * Neural or peripheral stimulator; * Foreign orbital or brain metallic foreign bodies; * Endoprostheses implanted for less than 4 weeks and osteosynthesis materials placed for less than 6 weeks; * Claustrophobia. Related to near infra Red spectroscopy * Hairs that do not allow proper near infra Red spectroscopy measurement upon ligh blockage Study B * Minimum age : 18 Years * Maximum Age : 25 Years * Sex : women Inclusion Criteria : * Normal BMI (18.5-25), * Right-handlers * Affiliated to a social security scheme * Having given a free, informed and written consent * Based on emotional overeating questionary : having emotional overeating episodes \> 6 days in a month for at least one negative emotion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cortico-striatal connectivity | 4 weeks | Significant change in cortico-striatal connectivity as determined with resting state functional magnetic resonance imaging correlation coefficient between the first magnetic resonance imaging and the last magnetic resonance imaging visit |
Countries
France
Contacts
Primary ContactLoïc JACOB
Backup ContactNicolas COQUERY, PhD
Outcome results
None listed