Breast Cancer, Cardiac Event
Conditions
Brief summary
Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.
Detailed description
Women with left-sided breast cancer undergo hypofractionated RT at either free-breathing or deep inspiration breath-hold. The incidence and potential clinical, dosimetric and biological indicators of early clinical or subclinical cardiac injury are investigate at 2 years.
Interventions
DEVICEDeep inspiration breath-hold technique
Selective application of deep inspiration breath-hold technique
Sponsors
Shu lian Wang
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Inclusion criteria
* Primary left-sided breast cancer post surgery * Planning for adjuvant breast/chest wall +-RNI
Exclusion criteria
* History of cardiovascular disease * Previous chest radiation * Bilateral breast cancers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of clinical or subclinical cardiac injury | two years | predefined cardiac events |
Countries
China
Contacts
Primary ContactShu-Lian Wang
Outcome results
None listed