Anterior MI, Colchicine
Conditions
Brief summary
Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography longitudinal strain pattern
Detailed description
The study participants are patients presented with anterior myocardial infarction. They will be divided into 2 groups. The first group will receive colchicine loading dose of 1mg then 0.5 mg maintenance dose in addition to the standard anti ischemic treatment for 6 months. The other group will only receive the standard anti ischmic treatment. Speckle tracking echocardiography will be done to all patients to assess left ventricular longitudinal strain pattern.
Interventions
Colchicine loading dose 1 mg and maintenance dose 0.5 mg for 6 months in addition to standard anti ischemic treatment.
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
▪︎Anterior S-T segment elevation myocardial infarction with time of presentation less than 12 hours.
Exclusion criteria
* Severe renal impairment. * Cardiac arrest. * Cardiogenic shock.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Average of global longitudinal strain pattern | 6 months | Assessment of left ventricular longitudinal strain by speckle tracking echocardiography after beforr and after colchicine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of mortality during study | 6 months | Death from any cause |
Countries
Egypt
Outcome results
None listed