Better Disease Control by Multidrug Regimen in Scabies

Better Disease Control by Multidrug Regimen in Scabies: A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05198947

Enrollment

212

Registered

2022-01-20

Start date

2017-01-31

Completion date

2018-07-31

Last updated

2022-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scabies

Keywords

Scabies, Permethrin, Ivermectin, Combination Regimen

Brief summary

Scabies is associated with significant discomfort and social taboo. Existing treatment regimen frequently fails due to lack of patient compliance. We compared single use regimen to existing standard repeat application regimen for treatment of scabies.

Interventions

DRUGPermethrin Lotion 5%

Topical permethrin 5% lotion to apply on day 1 and repeat after 1 week.

DRUGPermethrin Lotion 5% and Oral Ivermectin 200 mcg/kg

Topical permethrin 5% lotion and oral ivermectin 200 mcg/kg to be taken on day 1 only.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

5 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Willing patients * Clinical diagnosis of scabies * Within the age limits

Exclusion criteria

* Unwilling patients * Patients with severe co-morbidities requiring long term medication * Pregnant women * Patients who don't fulfill the age limit criteria

Design outcomes

Primary

Measure	Time frame	Description
Pruritus	1 month	Rate of relief from pruritus assessed using visual analog scale

Secondary

Measure	Time frame	Description
Skin lesions	1 month	Rate of eradication of skin lesions assessed using physician global assessment scale

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026