Myocardial Injury, Trigeminal Cardiac Reflex
Conditions
Brief summary
Myocardial injury after noncardiac surgery is significantly related to postoperative 30-day mortality. Trigeminal cardiac reflex is one of the main causes of perioperative cardiac emergency. Therefore, the investigators' aim is to test the hypothesis that trigeminal cardiac reflex associates postoperative myocardial damage in participants undergoing skull base tumor surgery. The investigators will observe the association between trigeminal cardiac reflex and myocardial injury by measuring the concentration of plasma high sensitivity cardiac troponin (hs-cTnT) in participants after skull base tumor surgery.
Interventions
OTHERTrigeminal cardiac reflex
Trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.
OTHERNon-trigeminal cardiac reflex
No trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.
Sponsors
Beijing Tiantan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective skull base tumor surgery. * Age ≥ 18 years old. * ASA class I to III. * All those who sign the informed consent form.
Exclusion criteria
* Patients with severe heart disease (including patients with preoperative heart rate \< 50 beats / min, severe arrhythmias, such as premature beats, paroxysmal supraventricular tachycardia, atrial flutter or fibrillation, patients with myocardial ischemia \< 6 months, heart failure, myocarditis, pericarditis or cardiomyopathy). * Patients unable to complete preoperative cardiac assessment. * Patients with chronic kidney disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of postoperative myocardial injury | Postoperative 1 day. | the elevation of plasma high sensitivity cardiac troponin I (hs-cTnI) caused by myocardial ischemia or injury (exclude other causes such as sepsis, pulmonary embolism, atrial fibrillation, etc). The blood samples before and within 24 hours after operation will be collected and measured by Roche's fourth generation hs-cTnI. It is commonly defined as an elevation as any value above the 99th percentile upper reference limit for each specific troponin I assay |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The duration time of trigeminal cardiac reflex during skull base tumor surgery. | The whole skull base tumor surgery procedure. | The duration time of trigeminal cardiac reflex during skull base tumor surgery. |
Countries
China
Outcome results
None listed