Abdominal Aortic Aneurysm, COVID-19
Conditions
Keywords
Abdominal aortic Aneurysm, Biomechanics, Rupture risk, Predictability, COVID-19
Brief summary
The acute phase of the COVID-19 pandemic requires a redefinition of healthcare system to increase the number of available intensive care units for COVID-19 patients. This leads to the postponing of elective surgeries including the treatment of abdominal aortic aneurysm (AAA). The probabilistic rupture risk index (PRRI) recently showed its advantage over the diameter criterion in AAA rupture risk assessment. Its major improvement is in increased specificity and yet has the same sensitivity as the maximal diameter criterion. The objective of this study was to test the clinical applicability of the PRRI diagnostic method in a quasi-prospective observational patient cohort study.
Interventions
DIAGNOSTIC_TESTBiomechanical rupture risk assessment
3D computational model is created from CT angiographic images available during standard AAA diagnostic process. Vascular wall stress is assessed based on the 3D model using Finite element method to identify highly stressed parts of AAA and results are compared to populational wall strength information (gathered from previous large histological study), thus rupture risk (stress/strength ratio) of each particular AAA is estimated. Other relevant factors such as gender, blood pressure, presence of intraluminal thrombus etc. are used during the calculation as well.
Sponsors
VSB - Technical University of Ostrava
Masaryk University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* presence of asymptomatic abdominal aortic aneurysm (AAA) * regular CT angiography scans available
Exclusion criteria
* rupture of AAA
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Test the clinical applicability of the BRRA method | 21 months | Identify the number of number of false positive and false negative cases assessed by BRRA method according to clinical data and compare these data to control group where the decision making process was based only on maximal diameter of AAA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reduction of time required for AAA assessment | 21 months | To investigate the feasibility of cooperation between the biomechanical and medical teams in a modified AAA management workflow leading to reduced time required for an AAA assessment |
Countries
Czechia
Outcome results
None listed