Trauma, Brain
Conditions
Brief summary
The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI.
Detailed description
The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma . Patients will be randomly assigned into two groups by sealed envelope technique into two equal groups. Parameters assessment: * Length of ICU stay * Length of total hospital stay * CT scan to exclude another intracranial hemorrhage or increase in hemorrhage * Functional status will be assessed using the GCS * Hemodynamic data ( bl.p / hr ) * Crystalloid volume that patient need in 24h * Mortality rate
Interventions
DRUGPropranolol
intravenous propranolol for case patients
DRUGSaline
intravenous saline for placebo
Sponsors
Menoufia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
16 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* GCS preoperative \>10 * Abbreviated Injury Scale (AIS) \>3 * Length stay in ICU \>48 h
Exclusion criteria
* Hypersensitivity to propranolol * Asthmatic patient * COPD * History of smoking * Any cardiac problems eg: ( heart failure or HB ) * pheochromocytoma * Pregnant patient * Length stay \<48h * Death within 48 h of admission * Patient who previously received any beta blocker at home. * Symptomatic Bradycardia \<60 b/m (sick sinus syndrome) * Hemodynamic unstable patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| survival | 7 days | number of surviving in patients receiving propranolol and patients who did not receive any beta blocker |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| heart rate | 7 days | number of patient showing effect of beta blocker on TBI related to HR |
| icu stay | 7 days | number of patients were beta blocker in TBI affected on ICU and total hospital stay |
Countries
Egypt
Outcome results
None listed