ASD, Eye Tracking, Functional Magnetic Resonance Imaging, Joint Attention, Social Cognition
Conditions
Keywords
ASD, Functional magnetic resonance imaging, Eye Tracking, social cognition, joint attention
Brief summary
Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, which is an essential step in achieving joint attention. The originality of this study is to improve the design of visual percepts (in the form of video) in order to mimic an ecological environment as much as possible by using MRI-ET coupling. The second originality of this study is the longitudinal exploration of the neurodevelopment of social cognition in autistic children. Studies by the Redcay and Oberwelland teams observe different activations at different ages. The hypothesis is that the perception of joint attention varies over time in people with ASD. To date, there are no studies to determine the influence of childhood neurodevelopment in autistic people on the perception of joint attention. It would be unprecedented to use the MRI-ET pairing as a tool for assessing social cognition as a function of the development of children with ASD.
Interventions
OTHERMRI-ET
coupled fMRI and Eye Tracking tools
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 20 Years
Healthy volunteers
Yes
Inclusion criteria
For the group of people with Autism Spectrum Disorders (experimental group): * Age between 10 to 20 years old * Diagnosis of ASD (CARS) ≥ 30 performed at inclusion * IQ test evaluation (regardless of the result) performed by a trained psychologist * Obtaining informed oral and written consent after appropriate information * Obtaining informed oral and written consent from the legal guardian after information * Be affiliated with social security * No contraindication to magnetic resonance imaging For the TD (Typical Development) group of people (control group): * Age between 10 to 20 years old * Diagnosis of ASD (CARS) \<30 performed at inclusion * IQ test evaluation (regardless of the result) performed by a trained psychologist * Obtaining informed oral and written consent after appropriate information * Obtaining informed oral and written consent from the legal guardian after information * Be affiliated with social security * No contraindication to magnetic resonance imaging
Exclusion criteria
For all groups: * Age outside the range 10 to 20 years * Person with a contraindication to MRI (including claustrophobia, pace maker, neurosurgical clips, vascular clips, heart valves, ventriculoperitoneal valves, cochlear implant, neurostimulator, intraocular metal shards, joint prosthesis, etc.) * Person suffering from major obesity (\> 140 kg) not allowing him to enter the tunnel of the MRI machine (diameter \<70cm) * Pregnant or breastfeeding woman * Person under guardianship or guardianship or deprived of liberty by a judicial or administrative decision For TD people (control group): * Person with psychiatric disorders such as attention disorder with or without hyperactivity, depression, bipolar disorder and schizophrenia. * Person with a neurological history such as epilepsy and / or neurovascular accident.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| difference of mapping IRM-ET results between both patient groups | one day | both patient groups are : the group of people with Autism Spectrum Disorders and Typical Development group of people |
Countries
France
Contacts
Primary ContactJean-Marc Constans, Pr
Outcome results
None listed