Noninvasive Ventilation
Conditions
Brief summary
Current study aimed to explore the effect of high PEEP during noninvasive ventilation among hypoxemic patients with acute respiratory failure.
Detailed description
This was a 1:1 randomized control trial to explore the effect of high versus low PEEP in noninvasive ventilation hypoxemic patients with acute respiratory failure. Several ICUs in China performed this study. In the high PEEP group, the PEEP maintained at 10-15 cmH2O, the inspiratory pressure maintained at 15-20 cmH2O. In the low PEEP group, the PEEP maintained at 5 cmH2O, the inspiratory pressure maintained at 10-20 cmH2O. The primary outcome was incidence of noninvasive ventilation failrue.
Interventions
PROCEDUREDifferent level of PEEP
Different level of PEEP (low versus high) was applied in noninvasive ventilation.
Sponsors
Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Low versus high PEEP
Eligibility
Sex/Gender
ALL
Age
16 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age between 16 and 85 years * use of dedicated noninvasive ventilator * PaCO2 ≤50 mmHg * PaO2/FiO2 ≤300mmHg * expectation of noninvasive ventilation \>12 hours * consciousness (Kelly score ≤3 or GCS≥13)
Exclusion criteria
* use of noninvasive ventilation before randomization \> 24 hours * use of noninvasive ventilation due to heart failure, asthma, acute excerbation of COPD * presence of contraindication of noninvasive ventilation such as malformation, rencent pulmonary or esophageal surgery et al. * end stage disease (expectation of life \< 6 months) * pneumothorax * noninvasive ventilation intolerance * refusal of paticipation * pregant woman * requirement of emergency intubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of noninvasive ventilation failure | From randomization to 28 days of study | Noninvasive ventilation failure was defined as intubation, death or withdrawal of therapy during noninvasive ventilation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | From randomization to 28 days of study | Died within 28 days of study |
| Duration of noninvasive ventilation | From beginning to 28 days of study | The days spent on noninvasive ventilation |
| Duration of invasive mechanical ventilation | From randomization to 28 days of study | The days spent on invasive ventilation |
| Side effect | From randomization to 28 days of study | Side effect included the incidence of pressure ulcer, pneumothorax, vomitting, aspiration and dryness |
| Length of stay in hospital | From beginning to 28 days of study | The days spent in hospital |
| The changes of PaO2/FiO2 | From randomization to 28 days of study | Oxygenation was calculated as PaO2/FiO2. |
| Length of stay in ICU | From beginning to 28 days of study | The days spent in ICU |
Countries
China
Outcome results
None listed