Vasopressor Preload Modulation During General Anaesthesia

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05193097

Enrollment

Registered

2022-01-14

Start date

2022-01-03

Completion date

2023-03-31

Last updated

2022-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

monitoring, cardiac output, perfusion index

Brief summary

Is is debated whether administration of pure vasopressor may augment cardiac output (CO) by means of preload modulation. We wish to test this in 20 patients under general anesthesia, with preload dependency induced by head-up-tilt and preload modulation with infusion of phenylephrine. To document any changes in CO the patients will be monitored by Lithium dilution method. Furthermore we will monitor changes in peripheral perfusion index and test the ability of this non-invasive modality to track changes in CO.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Planned surgery under general anesthesia

Exclusion criteria

* atrial fibrillation * refusal to participate

Design outcomes

Primary

Measure	Time frame
Changes in cardiac output	30 minutes
Changes in peripheral perfusion index	30 minutes

Contacts

Primary ContactJakob Højlund, MD

jakob.hoejlund@regionh.dk25708807

Outcome results