COVID-19 Acute Respiratory Distress Syndrome, Diaphragm Injury, Pathology, Ventilation Therapy; Complications
Conditions
Brief summary
The diaphragm is the fundamental muscle of the respiratory system. The diaphragmatic dysfunction is present in 60% of critical patients at hospital admission and up to 80% after prolonged mechanical ventilation and difficult weaning. Risk factors associated with diaphragm dysfunction and atrophy are sepsis, trauma, sedatives, steroids, and muscle relaxants. The main pathology characteristics of diaphragm biopsies of mechanically ventilated patients are atrophy and a reduction in contractility, determining an impact on the clinical outcome. Shi et al. found a higher section area of the diaphragm muscle fiber in biopsies of post mortem COVID-19 patients versus negative patients, independently from days of mechanical ventilation. The hypothesis of our study is to identify different clusters of pathological presentation in post-mortem COVID-19 mechanically ventilated patients.
Interventions
None listed
Sponsors
Azienda Sanitaria-Universitaria Integrata di Udine
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* patients deceased in the intensive care unit positive to SARS-CoV-2 and mechanically ventilated * post-mortem examination of the diaphragm
Exclusion criteria
* patients with a terminal disease and a prognosis of less than 48 hours at admission.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical characteristics | One week post mortem | Evaluate if there are specific clusters in the study population and find different clinical characteristics. |
| Blood test characteristics | One week post mortem | Evaluate if there are specific clusters in the study population and find different blood test characteristics. |
| Pathology characteristics | One week post mortem | Evaluate if there are specific clusters in the study population and find different pathology characteristics. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mechanical ventilation | One week post mortem | Verify if there are correlations between the clusters characteristics and the other variables in the study population mechanical ventilation. |
| Therapy | One week post mortem | Verify if there are correlations between the clusters characteristics and therapy in the study population. |
| Arterial blood gas analysis | One week post mortem | Verify if there are correlations between the clusters characteristics and arterial blood gas in the study population. |
Countries
Italy
Contacts
Primary ContactLuigi Vetrugno, MD
Outcome results
None listed