Aging, Antioxidative Stress
Conditions
Brief summary
The primary purpose of the present study is to evaluate the effects of MelaGene on anti-aging and anti-oxidant.
Interventions
DIETARY_SUPPLEMENTPlacebo drink
consume 1 bottle per day for 8 weeks
DIETARY_SUPPLEMENTMelaGene drink
consume 1 bottle per day for 8 weeks
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 30 to 65-year-old; * Must read and sign the informed consent form before the experiment; * People who are willing to cooperate with contraception during the trial period; * Do not change lifestyle and eating habits arbitrarily during the trial period; * Do not take supplementary foods and health supplements with the same efficacy two weeks before and during the test; * If any adverse reaction occurs during the experiment, subjects should be notified the researcher immediately.
Exclusion criteria
* Subject who is not willing to participate in this study; * Vegetarians; * People with a history of organ transplantation, epilepsy or convulsions, liver and kidney disease, malignant tumors, endocrine diseases, mental illness, alcohol or drug abuse, and other major organic diseases (according to medical history); * Participate in other clinical trials related to antioxidants and anti-aging four weeks before and during the test; * People with a history of dyspepsia would affect the absorption of the test product; * Allergic to the components of the test product; * Pregnant or breast-feeding women; * Take anti-oxidant supplements; * Undergoing hormone replacement therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of blood lipid (Triglyceride, total cholestrol, HDL-C, LDL-C) | Days 1, 28, and 56 | Venous blood is sampled to measure concentrations of blood lipid (Triglyceride, total cholestrol, HDL-C, LDL-C) |
| The change of cardiovascular endurance | Days 1, 28, and 56 | Step test is designed to assess cardiovascular endurance |
| The change of blood antioxidants(f-Thiols, t-GSH, GST-RBC, SOD, Total Anit-oxidative Capicity) | Days 1, 28, and 56 | Venous blood is sampled to measure concentrations of blood antioxidants(f-Thiols, t-GSH, GST-RBC, SOD, Total Anit-oxidative Capicity) |
| The change of ALT and AST | Days 1, 28, and 56 | Venous blood is sampled to measure concentrations of ALT and AST |
| The change of MDA | Days 1, 28, and 56 | Venous blood is sampled to measure concentrations of MDA |
| The change of anti-aging gene expression | Days 1, 28, and 56 | Venous blood is sampled to measure expression of anti-aging gene |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of continuous attention test | Days 1, 28, and 56 | Continuous attention test is designed to assess cognitive performance |
| The change of fatigue condition | Days 1, 28, and 56 | BFI-Taiwan Form is collected to assess fatigue condition |
Countries
Taiwan
Outcome results
None listed