EEG With Periodic Abnormalities, Obsessive-Compulsive Disorder
Conditions
Keywords
Obsessive compulsive disorder, Deep Transcranial Magnetic Stimulation, Mood, Quality of Life, EEG
Brief summary
Obsessive Compulsive Disorder (OCD) is a psychiatric disorder in which involuntary thoughts and irresistible behaviors are seen and its prevalence affects 2%-3% of the general population. Deep TMS is a treatment method that provides stimulation of lower parts of the brain and larger brain volume, and in addition to drug treatment and psychotherapy approaches, magnetic stimulation of localized brain regions and disease symptoms are addressed. The presence of the medial prefrontal cortex and anterior cingulate cortex in the dysfunction on the specified cycle seen in OCD patients indicates that the stimulation of these regions is necessary for a meaningful result in the treatment of deep TMS; studies show that the effect of the deep TMS method emerges as a result of the stimulation of these regions. 30 patients with OCD will included into the study and dividen into 3 groups (DTMS (n=10), DTMS + Paroxetine (n=10), Control(n=10)). Patients will evaluated in terms of depression, quality of life, and EEG before and after the intervention.
Interventions
Deep TMS, unlike traditional TMS, is a treatment method that provides stimulation of lower parts of the brain and larger brain volume, in addition to drug treatment and psychotherapy approaches, in addition to localized brain regions magnetic stimulation is a treatment method where disease symptoms are addressed.
DRUGParoxetine
Paroxetine is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It's often used to treat depression.
Sponsors
Istanbul Medipol University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Being diagnosed with Obsessive Compulsive Disorder within the framework of DSM-5 criteria
Exclusion criteria
* Not volunteering to comply with the research program * Presence of a metal piece on the head * Having a pacemaker inserted * Having had a previous epileptic seizure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electroencephalography | 6 weeks after baseline | It is an electrophysiological neuroimaging method frequently used in neuroscience and clinic, in which the activity between neural circuits can be measured and observed non-invasively in the form of electrical waves. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Beck Depression Scale | 6 weeks after baseline | It is the scale used for evaluated the level of depression. Higher score means worse result. |
| World Health Organization Quality of Life Scale Short Form | 6 weeks after baseline | It is the scale used for evaluated the level of quality of life. It contains a total of 26 questions. Higher score means better result. |
Countries
Turkey (Türkiye)
Outcome results
None listed