Hodgkin Disease, Lymphoma, Non-Hodgkin, Young Adults
Conditions
Keywords
physical fitness, fat oxidation, metabolism, exercise
Brief summary
Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle. Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population. Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) . The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.
Interventions
OTHERIndirect calorimetric test during submaximal exercise
* metabolic evaluation by indirect calorimetry at rest and during exercise * evaluation of cardiac output * peripheral quantitative computed tomography (pQCT) of the muscle cross section * evaluation of body composition * assessment of physical capacity (chair test and 3 min step-test) * blood test * assess the level of physical activity
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
group 1: healthy controls group 2 : young adults recovered from lymphoma or Hodgkin's disease
Eligibility
Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Young adult male or female, aged 18 to 25 * giving free and informed consent * Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage * Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease
Exclusion criteria
* Legal incapable adults * People under judicial protection * Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests * Medical contraindication to the practice of physical exercise * Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass * Any treatment that may have an influence on the energy metabolism * Active infection * Pregnant, breastfeeding, or likely to be * Subject's refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fat oxidation rate | day at 11:30 am during one day | maximum rate of lipid oxidation (in mg/ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood insulinemia | at 07:30 am in fasted condition during one day | blood value of insulin in pmol/L |
| blood N-terminal pro-B natriuretic peptide | at 07:30 am in fasted condition during one day | blood N-terminal pro-B natriuretic peptide level in g/L |
| blood troponin | at 07:30 am in fasted condition during one day | blood troponin level in g/L |
| blood lipids | at 07:30 am in fasted condition during one day | blood lipids level in g/L |
| blood glucose | at 07:30 am in fasted condition during one day | blood glucose level in g/L |
| Body composition: fat | at 07:30 am during one day | percentage of fat |
| rest metabolism | at 08:00 am in fasted condition during one day | energy expenditure at rest in kcal. |
| cardiac output | at 11:30 am during one day | Systolic Ejection Volume in mL evaluated at rest and during submaximal exercise |
| peripheral quantitative computed tomography | at 10:45 am during one day | Cross-sectional area of thigh muscles and intermuscular adipose tissue were assessed for muscle at 40% of the length between the greater trochanter and the mid-patella of the right leg |
| physical condition | at 08:45 am during one day | 3 min step-test (number of ascent / descent step) |
| physical capacity | at 08:45 am during one day | chair test (time in second held in position) |
| physical activity level | from day 2 to day 5 | daily energy expenditure (in Kcal) |
| sedentary level | from day 2 to day 5 | total sedentary time (in min) evaluated by accelerometer for 4 days |
| Body composition: lean mass | at 07:30 am during one day | percentage of lean mass |
Countries
France
Outcome results
None listed