Cardiovascular Diseases, Coronary Artery Disease, COVID-19
Conditions
Brief summary
It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19). However, the impact of subclinical respiratory and cardiovascular disease on the outcome of patients with COVID-19 is currently unknown. This observational study will assess the impact of incidental cardiovascular calcification on radiological imaging on the outcomes of patients with COVD-19.
Detailed description
It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19). However, the impact of subclinical respiratory and cardiovascular disease on the outcome of patients with COVID-19 is currently unknown. Subclinical respiratory and cardiovascular disease can be identified on radiological imaging. For example, calcification in blood vessels can identify cardiovascular disease, intra-thoracic and intra-abdominal fat is associated with coronary artery disease, and lung diseases can be identified on CT and x-ray. The impact these radiological features on the outcomes of patients with COVID-19 is currently unknown. This study aims to assess the radiological imaging of patients tested for COVID-19 in order to identify the presence of co-existing respiratory and cardiovascular disease and assess their impact on clinical outcomes. All patients tested for COVID-19 with current or previous (last 3 years) radiological imaging will be included in this study. Radiological images will be de-identified and assessed for the presence of cardiovascular calcification. Information on COVID-19 tests and clinical factors will be obtained from routinely collected data. Additional clinical information will be obtained from electronic health records as required.
Interventions
None listed
Sponsors
University of Edinburgh
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* One or more positive RT-PCR test for COVID-19. * One or more CT or chest x-ray available performed within the last 3 years
Exclusion criteria
* No available radiological imaging within the last 3 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All cause mortality | 1 month | All cause mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular mortality | 1 month | Cardiovascular mortality |
Other
| Measure | Time frame | Description |
|---|---|---|
| Myocardial infarction | 1 month | Myocardial infarction |
Countries
United Kingdom
Outcome results
None listed