Healthy Adults
Conditions
Brief summary
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health. The investigators will further investigate the affect of Beetroot juice on the vascular function of all participants.
Detailed description
African Americans and Hispanic individuals have the highest incidence of type 2 diabetes, which increases their risk of all cardiovascular diseases. One of the hallmarks of type 2 diabetes is vascular dysfunction, caused by a lack of nitric oxide bioavailability. Vascular function and blood flow responses to exercise have been shown to improve after nitrate supplementation (beetroot juice), However, whether nitrate supplementation will improve vascular function in African American and Hispanic individuals remains unknown. The investigators will perform a randomized, placebo-controlled study in healthy African American, Hispanic and Caucasian subjects. They will be studied before and 90 minutes after consuming Beetroot juice (high nitrate supplement) or Placebo, with at least 1-week washout period between the two visits (Kenjale AA et al., J Appl Physiol 2011).
Interventions
DIETARY_SUPPLEMENTBeetroot juice
high nitrate supplement
DIETARY_SUPPLEMENTPlacebo drink
placebo
Sponsors
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
it will be double blinded
Intervention model description
randomized, cross-over, placebo-controlled trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women who are either Caucasian American, Hispanic, or non-Hispanic African American
Exclusion criteria
* Blood pressure higher than or equal to 140/90 mmHg * BMI \> 35kg/m2 * Have a history of cardiovascular, neurological or vascular diseases * Take prescription medications * Are smokers * Are pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Forearm blood flow | through study completion, an average of 2 year | Blood flow of the brachial artery will be measured continuously at rest, during 3 min of handgrip exercise and for up to 1 min after the cessation of handgrip exercise. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Flow mediated vasodilation | through study completion, an average of 2 year | The subjects will lay supine with arm extended on a side table. Resting brachial artery diameter and velocity will be measured at rest for 2 min. Following this, a pneumatic cuff will be inflated on the forearm to supersystolic pressure (220-240 Torr) for 5 min and once the cuff is released, brachial artery diameter and velocity will be measured for up to 3 minutes after cuff deflation. FMD% will be calculated as (highest diameter after cuff deflation - baseline brachial artery diameter)/ baseline diameter \* 100 |
Countries
United States
Contacts
Primary Contactjasdeep kaur, PhD
Outcome results
None listed