Abdominal Surgery, Intra-abdominal Infection, Postoperative Fever, Postoperative Infection
Conditions
Brief summary
This is a prospective and exploratory study, which utilizes non-targeted metagenomic next-generation sequencing (mNGS) detecting drain fluid from patients who are suspected of postoperative abdominal infection. This study aims to explore the clinical value of mNGS in the rapid diagnosis of postoperative abdominal infection, to refine the pathogenic bacteria spectrum, and to establish a novel procedure for postoperative abdominal infection diagnosis.
Interventions
None listed
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Patients who receive abdominal operations with routinely abdominal drainage placement. 2. Abdominal infection is suspected by the clinicians, and one of the following conditions is met: 1. Temperature ≥38℃; 2. One of the following laboratory indicators: WBC≥10×10\^9/L, PCT≥0.5ng/ml, hsCRP≥100mg/L.
Exclusion criteria
1. Patients who are diagnosed with the abdominal infection before surgery. 2. Evidence of non-abdominal infection is clear and could explain the clinical symptoms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The pathogenic spectrum of postoperative abdominal infection | Through study completion, an average of 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Consistency between mNGS and conventional culture methods | Through study completion, an average of 1 year |
Countries
China
Outcome results
None listed